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Enhancement of ion activation and collision-induced dissociation by simultaneous dipolar excitation of ions in x - And y -directions in a linear ion trap 期刊论文

编号：

57c4d641-1202-4313-972f-a4119aa572bb
作者：

DANG, Qiankun[0]^[1] XU, Fuxing[1]^[2] Xie, Xiaodong[2]^[3] Xu, Chongsheng[3]^[3] Dai, Xinhua[4]^[4] Fang, Xiang[5]^[5] Ding, Li[6]^[6] DING, Chuanfan[7]^[7]
地址：

[1]Fudan University, Department of Chemistry and Laser Chemistry Institute,Shanghai,China
[2]Fudan University, Department of Electronics Engineering,Shanghai,China
[3]Fudan University, Department of Chemistry,Shanghai,China
[4]University of California, San Diego, Section of Cell and Developmental Biology,San Diego,United States
[5]National Institute of Metrology China,Beijing,China
[6]China Pharmaceutical University, Department of Pharmaceutical Analysis,Nanjing,China
[7]Fudan University, School of Chemistry,Shanghai,China
语种：

英文
期刊：

Analytical Chemistry ISSN：0003-2700 2015 年 87 卷 11 期 (5561 - 5567)
收录：
摘要：

Collision-induced dissociation (CID) in linear ion traps is usually performed by applying a dipolar alternating current (AC) signal to one pair of electrodes, which results in ion excitation mainly in one direction. In this paper, we report simulation and experimental studies of the ion excitation in two coordinate directions by applying identical dipolar AC signals to two pairs of electrodes simultaneously. Theoretical analysis and simulation results demonstrate that the ion kinetic energy is higher than that using the conventional CID method. Experimental results show that more activation energy (as determined by the intensity ratio of the a4/b4 fragments from the CID of protonated leucine enkephalin) can be deposited into parent ions in this method. The dissociation rate constant in this method was about 3.8 times higher than that in the conventional method under the same experimental condition, at the Mathieu parameter qu (where u = x, y) value of 0.25. The ion fragmentation efficiency is also significantly improved. Compared with the conventional method, the smaller qu value can be used in this method to obtain the same internal energy deposited into ions. Consequently, the "low mass cut-off" is redeemed and more fragment ions can be detected. This excitation method can be implemented easily without changing any experimental parameters. © 2015 American Chemical Society.
推荐引用方式
GB/T 7714：

DANG Qiankun/56198101500[0],XU Fuxing/35212535800[1],Xie Xiaodong/56999233800[2], et al. Enhancement of ion activation and collision-induced dissociation by simultaneous dipolar excitation of ions in x - And y -directions in a linear ion trap [J].Analytical Chemistry,2015,87(11):5561-5567.
APA：

DANG Qiankun/56198101500[0],XU Fuxing/35212535800[1],Xie Xiaodong/56999233800[2],Xu Chongsheng/55654139900[3],&DING Chuanfan/55653896800[7].(2015).Enhancement of ion activation and collision-induced dissociation by simultaneous dipolar excitation of ions in x - And y -directions in a linear ion trap .Analytical Chemistry,87(11):5561-5567.
MLA：

DANG Qiankun/56198101500[0], et al. "Enhancement of ion activation and collision-induced dissociation by simultaneous dipolar excitation of ions in x - And y -directions in a linear ion trap" .Analytical Chemistry 87,11(2015):5561-5567.

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