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Serum tumor necrosis factor alpha levels are associated with new ischemic brain lesions after carotid artery stenting 期刊论文

编号：

57f25f57-6d9f-4a03-a676-f400fb58c6c8
作者：

Lin, Changpo(林长泼)#^[1]Tang, Xiao(唐骁)^[1]Shi, Zhenyu(史振宇)^[1]Zhang, Lu^[1];Yan, Dong(严栋)^[1]Niu, Cong(牛琮)^[2]Zhou, Min^[1];Wang, Lixin(王利新)^[1]Fu, Weiguo(符伟国)^[1]Guo, Daqiao(郭大乔)*^[1]
语种：

English
期刊：

JOURNAL OF VASCULAR SURGERY ISSN：0741-5214 2018 年 68 卷 3 期 (771 - 778) ; SEP
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摘要：

Objective: New diffusion-weighted imaging (DWI) lesions on magnetic resonance imaging (MRI) after carotid artery stenting (CAS) are associated with an increased risk of future cerebrovascular events. Therefore, we evaluated the association between the expression levels of serum inflammatory markers and new DWI lesions after CAS and the presence of intraplaque hemorrhage (IPH). We also explored the mechanisms underlying this association. Methods: A total of 225 inpatients with severe carotid artery stenosis were consecutively enrolled in this cohort study. Serum inflammatory marker levels were detected in all patients by enzyme-linked immunosorbent assay. In the final analysis, 128 patients who underwent CAS and received pretreatment and post-treatment MRI scans were enrolled. DWI was performed to detect new ischemia brain lesions. T1-weighted, T2-weighted, and time-of-flight sequences were also conducted to identify IPH. Results: Serum tumor necrosis factor alpha (TNF-alpha) levels were significantly higher in symptomatic patients as well as in IPH+ patients identified by carotid MRI. New DWI lesions were identified in 50% of patients after CAS. Univariate analysis showed that DWI+ patients after CAS exhibited older mean age, higher mean TNF-alpha levels, and more IPH on preoperative MRI and were less likely to have right carotid stenosis than DWI- patients. Multivariate logistic regression analyses revealed that serum TNF-alpha concentrations were associated with new DWI lesions after CAS (odds ratio, 1.245; 95% confidence interval, 1.068-1.451; P =.005). Finally, the specificity and sensitivity of serum TNF-alpha levels in predicting DWI+ patients after CAS were 0.828 and 0.453, respectively. Conclusions: Higher serum TNF-alpha levels are associated with a higher likelihood of new DWI lesions after CAS and the presence of IPH. Therefore, TNF-alpha is a potentially valuable predictor of acute ischemic cerebral lesions after CAS and the presence of IPH.
推荐引用方式
GB/T 7714：

Lin Changpo,Tang Xiao,Shi Zhenyu, et al. Serum tumor necrosis factor alpha levels are associated with new ischemic brain lesions after carotid artery stenting [J].JOURNAL OF VASCULAR SURGERY,2018,68(3):771-778.
APA：

Lin Changpo,Tang Xiao,Shi Zhenyu,Zhang Lu,&Guo Daqiao.(2018).Serum tumor necrosis factor alpha levels are associated with new ischemic brain lesions after carotid artery stenting .JOURNAL OF VASCULAR SURGERY,68(3):771-778.
MLA：

Lin Changpo, et al. "Serum tumor necrosis factor alpha levels are associated with new ischemic brain lesions after carotid artery stenting" .JOURNAL OF VASCULAR SURGERY 68,3(2018):771-778.

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