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Effects of Two Chinese Herbal Formulae for the Treatment of Moderate to Severe Stable Chronic Obstructive Pulmonary Disease: A Multicenter, Double-Blind, Randomized Controlled Trial 期刊论文

编号：

5809b00c-b0c8-4aa4-932c-faf421288e4b
作者：

Wang, Genfa(王根发)#^[1,2]Liu, Baojun(刘宝君)^[1,2]Cao, Yuxue^[1,2];Du, Yijie^[1,2];Zhang, Hongying(张红英)^[1,2]Luo, Qingli^[1,2];Li, Bei^[1,2];Wu, Jinfeng(吴金峰)^[1,2]Lv, Yubao(吕玉宝)^[1,2]Sun, Jing^[1,2];Jin, Hualiang(金华良)^[1,2]Wei, Kai^[1,2];Zhao, Zhengxiao(赵正晓)^[1,2]Kong, Lingwen(孔令雯)^[1,2]Zhou, Xianmei^[3];Miao, Qing^[4];Wang, Gang^[5];Zhou, Qingwei^[6];Dong, Jingcheng(董竞成)*^[1,2]
语种：

English
期刊：

PLOS ONE ISSN：1932-6203 2014 年 9 卷 8 期 ; AUG 13
收录：
摘要：

Objective: The study aims to evaluate the efficacy and safety of two Chinese herbal formulae for the treatment of stable COPD. Methods: A multicenter, double-blind, double-dummy, and randomized controlled trial (RCT) was conducted. All groups were treated with additional conventional medicines. There were a 6-month treatment and a 12-month follow-up for 5 times. Primary outcomes included lung function test, exacerbation frequency, score of SGRQ. Second outcomes consisted of 6MWD, BODE index, psychological field score, inflammatory factors and cortisol. Results: A total of 331 patients were randomly divided into two active treatment groups (Bushen Yiqi (BY) granule group, n = 109; Bushen Fangchuan (BF) tablet group, n = 109) and a placebo group (n = 113). Finally 262 patients completed the study. BY granule & BF tablet increased the values of VC, FEV1 (%) and FEV1/FVC (%), compared with placebo. BY granule improved PEF. Both treatments reduced acute exacerbation frequency (P = 0.067), BODE index and psychological field score, while improved 6MWD. In terms of descent rang of SGRQ score, both treatments increased (P = 0.01). Both treatments decreased inflammatory cytokines, such as IL-8, and IL-17(P = 0.0219). BY granule obviously descended IL-17(P<0.05), IL-1 beta (P = 0.05), IL-6, compared with placebo. They improved the level of IL-10 and cortisol. BY granule raised cortisol (P = 0.07) and decreased TNF-alpha. Both treatments slightly descended TGF-beta 1. In terms of safety, subject compliance and drug combination, there were no differences (P>0.05) among three groups. Conclusions: BY granule and BF tablet were positively effective for the treatment of COPD, and the former performed better in general.
推荐引用方式
GB/T 7714：

Wang Genfa,Liu Baojun,Cao Yuxue, et al. Effects of Two Chinese Herbal Formulae for the Treatment of Moderate to Severe Stable Chronic Obstructive Pulmonary Disease: A Multicenter, Double-Blind, Randomized Controlled Trial [J].PLOS ONE,2014,9(8).
APA：

Wang Genfa,Liu Baojun,Cao Yuxue,Du Yijie,&Dong Jingcheng.(2014).Effects of Two Chinese Herbal Formulae for the Treatment of Moderate to Severe Stable Chronic Obstructive Pulmonary Disease: A Multicenter, Double-Blind, Randomized Controlled Trial .PLOS ONE,9(8).
MLA：

Wang Genfa, et al. "Effects of Two Chinese Herbal Formulae for the Treatment of Moderate to Severe Stable Chronic Obstructive Pulmonary Disease: A Multicenter, Double-Blind, Randomized Controlled Trial" .PLOS ONE 9,8(2014).

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