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Effect of Body mass index on the performance characteristics of PSA-related markers to detect prostate cancer 期刊论文

编号：

587684a5-a633-41f8-9918-d31c0f5dc8b1
作者：

Zhu, Yao(朱耀)#^[1,2]Han, ChengTao(韩成涛)^[1,2]Zhang, GuiMing^[1,2];Liu, Fang^[3];Ding, Qiang(丁强)^[4,5]Xu, JianFeng^[3,4,5,6];Vidal, Adriana C.^[7];Freedland, Stephen J.^[7];Ng, ChiFai^[8];Ye, DingWei(叶定伟)^[1,2]
语种：

English
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2016 年 6 卷 ; JAN 12
收录：
摘要：

To examine whether the predictive performance of prostate-specific antigen (PSA) and PSA-related markers for prostate cancer (PCa) is modified by body mass index (BMI). Patients with a PSA 2-10 ng/mL who underwent multicore prostate biopsies were recruited from three tertiary centers. Serum markers measured included total PSA (tPSA), free-to-total PSA (f/tPSA), p2PSA, percentage of p2PSA (%p2PSA), and prostate health index (PHI). The association between serum markers and PCa risk was assessed by logistic regression. Predictive performance for each marker was quantified using the area under the receiver operator curves (AUC). Among 516 men, 18.2% had PCa at biopsy. For all tested markers, their predictive value on PCa risk was lower in obese patients compared to normal weight patients. We found statistically significant interactions between BMI and tPSA (P = 0.0026) and p2PSA (P = 0.038). PHI achieved an AUC of 0.872 in normal weight patients and 0.745 in obese patients, which outperformed the other predictors regardless of BMI category. In conclusion, PHI achieved the best predictive performance for detecting PCa and was not influenced by BMI.
推荐引用方式
GB/T 7714：

Zhu Yao,Han Cheng-Tao,Zhang Gui-Ming, et al. Effect of Body mass index on the performance characteristics of PSA-related markers to detect prostate cancer [J].SCIENTIFIC REPORTS,2016,6.
APA：

Zhu Yao,Han Cheng-Tao,Zhang Gui-Ming,Liu Fang,&Ye Ding-Wei.(2016).Effect of Body mass index on the performance characteristics of PSA-related markers to detect prostate cancer .SCIENTIFIC REPORTS,6.
MLA：

Zhu Yao, et al. "Effect of Body mass index on the performance characteristics of PSA-related markers to detect prostate cancer" .SCIENTIFIC REPORTS 6(2016).

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