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Tumor cytoreduction results in better response to androgen ablation-a preliminary report of palliative transurethral resection of the prostate in metastatic hormone sensitive prostate cancer 期刊论文

编号：

58eff36b-6450-4030-b182-f37e2981aee7
作者：

Qin, XiaoJian(秦晓健)#^[1,2]Ma, ChunGuang(马春光)^[1,2]Ye, DingWei(叶定伟)*^[1,2]Yao, XuDong(姚旭东)^[1,2]Zhang, ShiLin(张世林)^[1,2]Dai, Bo(戴波)^[1,2]Zhang, HaiLiang(张海梁)^[1,2]Shen, YiJun(沈益君)^[1,2]Zhu, Yao(朱耀)^[1,2]Zhu, YiPing(朱一平)^[1,2]Shi, GuoHai(施国海)^[1,2]Xiao, WenJun(肖文军)^[1,2]Lin, GuoWen(林国文)^[1,2]Swanson, Gregory P.^[3];
语种：

English
期刊：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS ISSN：1078-1439 2012 年 30 卷 2 期 (145 - 149) ; MAR-APR
收录：
关键词：

Cytoreductive surgery Hormone sensitive metastatic prostate cancer Hormone therapy Prognosis Transurethral resection of the prostate
摘要：

Objectives: To investigate the oncologic influence of transurethral resection of the prostate (TURP) as a cytoreductive surgery in metastatic hormone sensitive prostate cancer (mHSPC), in the setting of continuous complete androgen blockade (CAB). Materials and methods: Medical histories of 146 consecutive Chinese males with newly diagnosed mHSPC, registered in our institution in 2006 and 2007, were reviewed. All of these patients received CAB as initial systematic therapy. Demographics and cancer control outcomes from 39 mHSPC patients who underwent TURP for a relief of bladder outlet obstruction were compared with those of the other 107 who received CAB only when they were still hormone-sensitive. Median follow-up was 15 months (3 to 27 months). Results: Age at diagnosis, baseline PSA, and biopsy Gleason score were comparable between the 2 groups. Patients who underwent a TURP had lower PSA nadir (median 0.15 ng/ml vs. 0.82 ng/ml, P = 0.015) and longer time to PSA nadir (11.2 months vs. 6.4 months, P < 0.001). More patients in the non-TURP group developed hormone refractory prostate cancer (P = 0.007). The TURP group had a tendency towards longer disease-specific survival and overall survival (24.4 months vs. 24.1 months and 24.4 months vs. 22.9 months, respectively), though this did not reach statistical significance. Conclusions: TURP resulted in a better and more prolonged response to hormone therapy in mHSPC, with a trend towards positive influence in disease specific survival and overall survival. To date, our preliminary report is the first study regarding long-term survival of cytoreductive surgery in mHSPC, and further investigations are warranted. (C) 2012 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Qin Xiao-Jian,Ma Chun-Guang,Ye Ding-Wei, et al. Tumor cytoreduction results in better response to androgen ablation-a preliminary report of palliative transurethral resection of the prostate in metastatic hormone sensitive prostate cancer [J].UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS,2012,30(2):145-149.
APA：

Qin Xiao-Jian,Ma Chun-Guang,Ye Ding-Wei,Yao Xu-Dong,&Swanson Gregory P..(2012).Tumor cytoreduction results in better response to androgen ablation-a preliminary report of palliative transurethral resection of the prostate in metastatic hormone sensitive prostate cancer .UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS,30(2):145-149.
MLA：

Qin Xiao-Jian, et al. "Tumor cytoreduction results in better response to androgen ablation-a preliminary report of palliative transurethral resection of the prostate in metastatic hormone sensitive prostate cancer" .UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 30,2(2012):145-149.

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