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Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation 期刊论文

编号：

596c0319-4ec6-45ac-a43f-68704192a7d5
作者：

Zhou, Chun^[1];You, Yan^[1,2];Shen, Weixing^[4];Zhu, YiZhun(朱依谆)^[2]Peng, Jing^[1];Feng, HaoTian^[3];Wang, Ying^[1];Li, Dong^[1,2];Shao, WeiWei^[1];Li, CuiXian^[1];Li, WanZhen^[1,2];Xu, Jiake^[3];Shen, Xiaoyan(沈晓燕)*^[1,2]
语种：

English
期刊：

ANNALS OF THE RHEUMATIC DISEASES ISSN：0003-4967 2016 年 75 卷 6 期 (1211 - 1218) ; JUN
收录：
摘要：

Objective Periarticular and subchondral bone erosion in rheumatoid arthritis caused by osteoclast differentiation and activation is a critical index for diagnosis, therapy and monitoring of the disease. Sorting nexin (SNX) 10, a member of the SNX family which functions in regulation of endosomal sorting, has been implicated to play an important clinical role in malignant osteopetrosis. Here we studied the roles and precise mechanisms of SNX10 in the bone destruction of collagen-induced arthritis (CIA) mice. Methods The role of SNX10 in bone destruction was evaluated by a CIA mice model which was induced in male SNX10(-/-) mice and wild type littermates. The mechanism was explored in osteoclasts induced by receptor activator of nuclear factor kappa B ligand from bone marrow mononuclear cells of wild type and SNX10(-/-) mice. Results SNX10 knockout prevented bone loss and joint destruction in CIA mice with reduced serum levels of TNF-alpha, interleukin 1 beta and anticollagen IgG 2 alpha antibody. SNX10 deficiency did not block osteoclastogenesis, but significantly impaired osteoclast maturation and bone-resorption function by disturbing the formation of actin belt. The production of TRAP, CtsK and MMP9 in SNX10(-/-) osteoclasts was significantly inhibited, and partially restored by SNX10 overexpression. We further demonstrated that the degradation of NFATc1 was accelerated in SNX10(-/-) osteoclasts causing an inhibition of integrin beta 3-Src-PYK2 signalling. Conclusions Our study discloses a crucial role and novel mechanism for SNX10 in osteoclast function, and provides evidence for SNX10 as a promising novel therapeutic target for suppression of immune inflammation and bone erosion in rheumatoid arthritis.
推荐引用方式
GB/T 7714：

Zhou Chun,You Yan,Shen Weixing, et al. Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation [J].ANNALS OF THE RHEUMATIC DISEASES,2016,75(6):1211-1218.
APA：

Zhou Chun,You Yan,Shen Weixing,Zhu Yi-Zhun,&Shen Xiaoyan.(2016).Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation .ANNALS OF THE RHEUMATIC DISEASES,75(6):1211-1218.
MLA：

Zhou Chun, et al. "Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation" .ANNALS OF THE RHEUMATIC DISEASES 75,6(2016):1211-1218.

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