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Biomarker expression in normal fimbriae: Comparison of high- and low-grade serous ovarian carcinoma 期刊论文

编号：

59f55ee1-b3af-4807-a180-6e91387fdcb8
作者：

Zhang Xuyin^[1];Ding Jingxin^[1];Tao Xiang^[1];Jia Luoqi(贾罗琦)^[1]Hua Keqin^[1];
语种：

English
期刊：

ONCOLOGY LETTERS ISSN：1792-1074 2012 年 4 卷 5 期 (1008 - 1012) ; NOV
收录：
关键词：

high-grade serous low-grade serous fimbria phospho-AKT matrix metalloproteinase-2 E-cadherin vascular endothelial growth factor cyclooxygenase-2 p53
摘要：

The objective of this study. was to assess the difference in fimbriae of high- and low-grade ovarian serous carcinoma (OSC). The fimbriae of normal appearance [without serous tubal intraepithelial carcinoma (STIC)] from 28 patients with high-grade OSCs and 24 patients with low-grade OSCs were assessed for the expression of 6 markers [E-cadherin, matrix metalloproteinase-2 (MMP-2), phospho-AKT (pAKT), cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF) and p53] using immunohistochemistry. Sectioning and extensively examining the fimbria (SEE-FIM) was performed to exclude fimbrial involvement for all the cases. The immunostaining levels of pAKT and COX-2 were significantly higher in the fimbriae of normal appearance from high-grade OSCs compared with low-grade OSCs (61 vs. 8% and 71 vs. 21%; P=0.005 and 0.007, respectively). The immunostaining of E-cadherin was significantly higher in the fimbriae of low-grade OSCs compared with high-grade OSCs (83 vs. 21%; P=0.003). The remaining 3 markers (MMP-2, VEGF and p53) had similar expression in low- and high-grade OSCs (21 vs. 13%; 25 vs. 21%; and 14 vs. 8%; P=0.78, 0.86 and 0.82, respectively). Our results suggest marked biological differences in the behavior of the fimbriae in high- and low-grade OSCs and indicate that proliferation, cell adhesion and the inflammatory microenvironment of fimbriae in high-grade OSCs without STIC had changed prior to p53 mutation.
推荐引用方式
GB/T 7714：

Zhang Xuyin,Ding Jingxin,Tao Xiang, et al. Biomarker expression in normal fimbriae: Comparison of high- and low-grade serous ovarian carcinoma [J].ONCOLOGY LETTERS,2012,4(5):1008-1012.
APA：

Zhang Xuyin,Ding Jingxin,Tao Xiang,Jia Luoqi,&Hua Keqin.(2012).Biomarker expression in normal fimbriae: Comparison of high- and low-grade serous ovarian carcinoma .ONCOLOGY LETTERS,4(5):1008-1012.
MLA：

Zhang Xuyin, et al. "Biomarker expression in normal fimbriae: Comparison of high- and low-grade serous ovarian carcinoma" .ONCOLOGY LETTERS 4,5(2012):1008-1012.

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