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Tumor Angiogenesis Targeted Radiosensitization Therapy Using Gold Nanoprobes Guided by MRI/SPECT Imaging 期刊论文

编号：

5a02217a-f8b9-485c-a441-ea4b20a3c146
作者：

Yang, Yi^[1];Zhang, Lu^[1];Cai, Jiali^[2];Li, Xiao^[3];Cheng, Dengfeng(程登峰)^[3]Su, Huilan^[4];Zhang, Jianping^[5];Liu, Shiyuan^[2];Shi, Hongcheng(石洪成)^[3]Zhang, Yingjian(章英剑)^[5]Zhang, Chunfu^[1,6];
语种：

英文
期刊：

ACS APPLIED MATERIALS & INTERFACES ISSN：1944-8244 2016 年 8 卷 3 期 (1718 - 1732) ; JAN 27
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关键词：

gold nanoparticles radiotherapy MRI/SPECT alpha nu beta 3 integrin theranostics
摘要：

Gold nanoparticles (AuNPs) have recently garnered great interest as potential radiosensitizers in tumor therapy. However, major challenges facing their application in this regard are further enhancement of tumor accumulation of the particles in addition to enhanced permeability retention (EPR) effect and an understanding of the optimal particle size and time for applying radiotherapy after the particle administration. In this study, we fabricated novel cyclic c(RGDyC)-peptide-conjugated, Gd- and 99 mTc-labeled AuNPs (RGD@AuNPs-Gd99 mTc) probes with different sizes (29, 51, and 80 nm) and evaluated their potential as radiosensitization therapy both in vitro and in vivo. We found that these probes have a high specificity for alpha nu beta 3 integrin positive cells, which resulted in their high cellular uptake and thereby enhanced radiosensitization. Imaging in vivo with MRI and SPECT/CT directly showed that the RGD@AuNPs-Gd99 mTc probes specifically target tumors and exhibit greater accumulation within tumors than the RAD@AuNPsGd99 mTc probes. Interestingly, we found that the 80 nm RGD@AuNPs-Gd99 mTc probes exhibit the greatest effects in vitro; however, the 29 nm RGD@AuNPs-Gd99 mTc probes were clearly most efficient in vivo. As a result, radiotherapy of tumors with the 29 nm probe was the most potent. Our study demonstrates that RGD@AuNPs-Gd99 mTc probes are highly useful radiosensitizers capable of guiding and enhancing radiation therapy of tumors.
推荐引用方式
GB/T 7714：

Yang Yi,Zhang Lu,Cai Jiali, et al. Tumor Angiogenesis Targeted Radiosensitization Therapy Using Gold Nanoprobes Guided by MRI/SPECT Imaging [J].ACS APPLIED MATERIALS & INTERFACES,2016,8(3):1718-1732.
APA：

Yang Yi,Zhang Lu,Cai Jiali,Li Xiao,&Zhang Chunfu.(2016).Tumor Angiogenesis Targeted Radiosensitization Therapy Using Gold Nanoprobes Guided by MRI/SPECT Imaging .ACS APPLIED MATERIALS & INTERFACES,8(3):1718-1732.
MLA：

Yang Yi, et al. "Tumor Angiogenesis Targeted Radiosensitization Therapy Using Gold Nanoprobes Guided by MRI/SPECT Imaging" .ACS APPLIED MATERIALS & INTERFACES 8,3(2016):1718-1732.
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