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IL28B rs12979860 polymorphism does not influence outcomes of hepatitis B virus infection 期刊论文

编号：

5a6e1940-d21a-45d8-a5e7-8c6ccf3a5866
作者：

Peng, L. J.^[1,2] Guo, J. S.^[1] Zhang, Z.^[1] Shi, H.^[1] Wang, J.^[1] Wang, J. Y.^[1]
语种：

English
期刊：

TISSUE ANTIGENS ISSN：0001-2815 2012 年 79 卷 4 期 (302 - 305) ; APR
收录：
关键词：

hepatitis B interleukin 28B interferon-lamda 3 single nucleotide polymorphism
摘要：

rs12979860 in interleukin 28B (IL28B) gene is associated with response to interferon-a therapy and natural viral clearance in hepatitis C. The role of this polymorphism is less known in hepatitis B virus (HBV) infection. We evaluated whether rs12979860 was associated with outcomes of HBV infection. There were 651 individuals with persistent infection (387 with liver cirrhosis, 264 without cirrhosis) and 226 healthy individuals who recovered from HBV infection. The genotypic distributions were compared between different phenotypes pertaining to disease progression and HBV markers. The polymorphism had no association with clearance of hepatitis B surface antigen and hepatitis B e antigen, HBV-DNA level, apparent hepatitis onset and liver cirrhosis (P > 0.05). These results suggest that rs12979860 does not have such a strong effect in hepatitis B compared to hepatitis C.
推荐引用方式
GB/T 7714：

Peng L. J.,Guo J. S.,Zhang Z., et al. IL28B rs12979860 polymorphism does not influence outcomes of hepatitis B virus infection [J].TISSUE ANTIGENS,2012,79(4):302-305.
APA：

Peng L. J.,Guo J. S.,Zhang Z.,Shi H.,&Wang J. Y..(2012).IL28B rs12979860 polymorphism does not influence outcomes of hepatitis B virus infection .TISSUE ANTIGENS,79(4):302-305.
MLA：

Peng L. J., et al. "IL28B rs12979860 polymorphism does not influence outcomes of hepatitis B virus infection" .TISSUE ANTIGENS 79,4(2012):302-305.

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