[1]Harbin Medical University, Department of Biostatistics,Harbin,China
[2]Vanderbilt Ingram Cancer Center, Department of Medicine,Nashville,United States
[3]Cleveland Clinic Foundation, Genomic Medicine Institute,Cleveland,United States
[4]Renji Hospital, Shanghai Cancer Institute,Shanghai,China
[5]Renji Hospital, SKLORG & Department of Epidemiology,Shanghai,China
[6]Renji Hospital, Department of Epidemiology,Shanghai,China
[7]National Cancer Institute, Department of Health and Human Services,Bethesda,United States
[8]Medical Center of Fudan University, Department of Epidemiology,Shanghai,China
Objective: To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations. Methods: We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a population-based cohort study. Cox regression and logistic regression models were applied in data analysis. Results: After adjustment for potential confounding factors, we found that POF increased the risk of total and cancer-specific mortality (HR (95%CIs): 1.29 (1.08-1.54) and 1.38 (1.05-1.81), respectively). POF was also associated with high prevalence of autoimmune disease (OR (95%CI): 1.56 (1.04-2.35)) but decreased incidence of breast cancer (OR (95%CI): 0.59 (0.38-0.91)). Similar results were observed when hormone replacement therapy users were excluded from the analysis. POF is associated with high waist-to-hip ratio. Conclusions: Our results suggest that women with POF experience increased mortality and that these women may benefit from heightened surveillance and appropriate interventions. © 2014 Wu et al.