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Blood concentration, efficacy, and adverse events of phenobarbital: A prospective study in rural China 期刊论文

编号：

5caa922c-062f-405f-9722-76c33cb13fc2
作者：

Sun, Wanbing#^[1]Wang, Jianhong(王剑虹)*^[1]Ding, Ding(丁玎)*^[2]Zhang, Qing^[3];Wang, Taiping^[4];Hong, Zhen^[2];
语种：

英文
期刊：

EPILEPSY & BEHAVIOR ISSN：1525-5050 2019 年 90 卷 (247 - 251) ; JAN
收录：
关键词：

PB monotherapy Blood concentration Efficacy Adverse event
摘要：

Objective: This study evaluated the relationship between blood concentration of phenobarbital (PB) and its efficacy as well as adverse events in people with epilepsy in rural China.
Methods: People with epilepsy being treated with PB monotherapy were recruited and followed up for averagely 2.5 years. Data of clinical characteristics were collected using a standardized questionnaire by face-to-face interviews both at baseline and follow-up. Plasma concentration of PB was detected by the high-performance liquid chromatography.
Results: Data on treatment response and PB blood concentration was obtained from 225 subjects. Among them. 119 (52.9%) were recognized as effective cases and 106 (47.1%) as ineffective cases. In the effective group. the blood concentration of 95% subjects ranged from 122 mu g/ml to 41.36 mu g/ml with a median at 13.18 mu g/ml (IQR- 8.32-20.19 mu g/ml). The PB concentration of 95% of the subjects in the ineffective group ranged from 2.73 mu g/ml to 70.16 mu g/ml with a median at 19.80 mu g/ml (IQR - 11.30-30.40 mu g/ml), which was significantly higher than that of the effective group (p < 0.001). Multivariate logistic regression analysis showed that PB concentration >= 26.38 mu g/ml was related to a 4.5-fold (95% confidence interval [CI], 1.85-11.08) higher risk of inefficacy. A receiver operation characteristic curve was performed to determine the cutoff value of concentration for PB efficacy at 19.02 mu g/ml.
Significance: Blood concentration may bean important indicator for clinical decision making when PB monotherapy cannot achieve a good efficacy and more attention should be paid on it in clinical practice especially in resource-poor settings. (C) 2018 Published by Elsevier Inc.
推荐引用方式
GB/T 7714：

Sun Wanbing,Wang Jianhong,Ding Ding, et al. Blood concentration, efficacy, and adverse events of phenobarbital: A prospective study in rural China [J].EPILEPSY & BEHAVIOR,2019,90:247-251.
APA：

Sun Wanbing,Wang Jianhong,Ding Ding,Zhang Qing,&Hong Zhen.(2019).Blood concentration, efficacy, and adverse events of phenobarbital: A prospective study in rural China .EPILEPSY & BEHAVIOR,90:247-251.
MLA：

Sun Wanbing, et al. "Blood concentration, efficacy, and adverse events of phenobarbital: A prospective study in rural China" .EPILEPSY & BEHAVIOR 90(2019):247-251.
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