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Critical Role of Regulatory T Cells in the Latency and Stress-Induced Reactivation of HSV-1 期刊论文

编号：

5e13cd48-e0a6-431e-b8d1-9c6334fc3837
作者：

Yu, Wencong^[1,2,3];Geng, Shuang^[1,2,3,7];Suo, Yuanzhen^[4];Wei, Xunbin^[4];Cai, Qiliang(蔡启良)^[1,2,3]Wu, Bing^[1,2,3];Zhou, Xian^[1,2,3];Shi, Yan^[5,6];Wang, Bin(王宾)*^[1,2,3]
语种：

English
期刊：

CELL REPORTS ISSN：2211-1247 2018 年 25 卷 9 期 (2379 - +) ; NOV 27
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摘要：

Herpes simplex virus 1 (HSV-1) spreads in populations through a latency entry and reactivation cycle. The role of host immune-suppressive factor regulatory T cells (Treg cells) in controlling latency establishment and reactivation is not completely understood. Here, using an HSV-1 ocular infection murine model, we observe a positive correlation between the level of Treg cells and viral infectivity and demonstrate the requirement for Treg cells in latency establishment. Furthermore, we show that host stress leads to HSV-1 reactivation via increased Treg cell control of CD8(+) T cells, permitting viral replication under diminished immune surveillance. Together, we propose that Treg cell regulation may serve as a key target for controlling HSV infection.
推荐引用方式
GB/T 7714：

Yu Wencong,Geng Shuang,Suo Yuanzhen, et al. Critical Role of Regulatory T Cells in the Latency and Stress-Induced Reactivation of HSV-1 [J].CELL REPORTS,2018,25(9):2379-+.
APA：

Yu Wencong,Geng Shuang,Suo Yuanzhen,Wei Xunbin,&Wang Bin.(2018).Critical Role of Regulatory T Cells in the Latency and Stress-Induced Reactivation of HSV-1 .CELL REPORTS,25(9):2379-+.
MLA：

Yu Wencong, et al. "Critical Role of Regulatory T Cells in the Latency and Stress-Induced Reactivation of HSV-1" .CELL REPORTS 25,9(2018):2379-+.

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