Objectives: To analyze the prognostic value of microsatellite instability (MSI) in a population-based study of FIGO stage 1-4 endometrial endometrioid adenocarcinomas. Study design: Survival analysis in 273 patients of MSI status and clinico-pathologic features. Using a highly sensitive pentaplex polymerase chain reaction to establish MSI status, cases were divided into microsatellite stable (MSS), MSI-low (MSI-L, 1 marker positive) and MSI-high (MSI-H, 2-5 markers positive). Results: After 61 months median follow-up (1-209), 34 (12.5%) of the patients developed metastases but only 6.4% of the FIGO 1. MSI (especially as MSI-H vs. MSS/MSI-Lcombined) was prognostic in FIGO 1 but not in FIGO 2-4. The 5 and 10 year recurrence-free survival rates were 98% and 95% in the MSS/MSI-L vs. 85% and 73% in the MSI-H patients (p = 0.005). Conclusions: MSI-H status assessed by pentaplex polymerase chain reaction is an indicator of poor prognosis in FIGO 1, but not in FIGO 2-4 endometrial endometrioid adenocarcinomas.
[1]Stavanger Univ Hosp, Dept Pathol, N-4068 Stavanger, Norway;
[2]Stavanger Univ Hosp, Dept Gynaecol, N-4068 Stavanger, Norway;
[3]Univ Bergen, Gade Inst, Bergen, Norway;
[4]Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA;
[5]Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA;
[6]Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Cambridge CB2 2QQ, England;
[7]Acad Med Ctr, Dept Gynecol, Maastricht, Netherlands;
[8]Univ Texas MD Anderson Canc Ctr, Dept Expt Med, Houston, TX 77030 USA;
[9]Fudan Univ, Dept Gynecol, Obstet & Gynecol Hosp, Shanghai 200433, Peoples R China
(8.0+极速模式)