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Preparation and evaluation of chitosan-ethylenediaminetetraacetic acid hydrogel films for the mucoadhesive transbuccal delivery of insulin 期刊论文

编号：

60305f39-f105-4a11-adc5-33bd3d013271
作者：

Cui, Fuying^[1,2] He, Chunbai^[1,2] He, Miao^[2] Tang, Cui^[1] Yin, Lichen^[1] Qian, Feng^[2] Yin, Chunhua^[1,2]
语种：

英文
期刊：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A ISSN：1549-3296 2009 年 89A 卷 4 期 (1063 - 1071) ; JUN 15
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关键词：

bilaminated film chitosin-ethylenediaminetetraacetic acid hydrogel mucoadhesion transbuccal delivery system
摘要：

This manuscript describes the development of a new porous, flexible bilaminated film for buccal protein administration by a simple and mild casting procedure. It consists of a mucoadhesive layer (chitosan-ethylenediaminetetraacetic acid hydrogel film) containing protein drugs and an impermeable protective layer made of ethylcellose. The obtained mucoadhesive layer was characterized in terms of Fourier transform infrared spectroscopy, rheology, swelling, and mucoadhesion. Rheology results showed that chitosan-ethylenediaminetetraacetic acid hydrogel (10:2) possessed the greatest degree of viscoelasticity and was well-structured compared with other hydrogels. The in vitro mucoadhesion Studies also showed that the mucoadhesive force of the hydrogel remained over 17,000 N/m(2) during 4 h in the simulated oral cavity. The insulin loaded bilaminated film showed a pronounced hypoglycemic effect following buccal administration to healthy rats, achieving a 17% pharmacological availability comp, red with subcutaneous insulin injection. According to these results, the bilaminated film Would be a promising delivery carrier for protein drugs via the buccal route. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 1063-1071, 2009
推荐引用方式
GB/T 7714：

Cui Fuying,He Chunbai,He Miao, et al. Preparation and evaluation of chitosan-ethylenediaminetetraacetic acid hydrogel films for the mucoadhesive transbuccal delivery of insulin [J].JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2009,89A(4):1063-1071.
APA：

Cui Fuying,He Chunbai,He Miao,Tang Cui,&Yin Chunhua.(2009).Preparation and evaluation of chitosan-ethylenediaminetetraacetic acid hydrogel films for the mucoadhesive transbuccal delivery of insulin .JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,89A(4):1063-1071.
MLA：

Cui Fuying, et al. "Preparation and evaluation of chitosan-ethylenediaminetetraacetic acid hydrogel films for the mucoadhesive transbuccal delivery of insulin" .JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 89A,4(2009):1063-1071.

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