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Histotype differentiation of hypo-echoic renal tumors on CEUS: usefulness of enhancement homogeneity and intensity 期刊论文

编号：

613663b0-bedc-468a-876f-64eb9cd2a7a9
作者：

Lu, Qing(陆清)#^[1]Xue, Liyun(薛立云)^[1]Huang, Beijian(黄备建)*^[1]Wang, Wenping(王文平)^[1]Li, Cuixian(李翠仙)^[1]
语种：

English
期刊：

ABDOMINAL IMAGING ISSN：0942-8925 2015 年 40 卷 6 期 (1675 - 1683) ; AUG
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关键词：

Histotype Renal tumor Contrast-enhanced ultrasound Quantitative analysis
摘要：

The purpose of this study is to evaluate qualitative and quantitative analysis of contrast-enhanced ultrasound (CEUS) in differential diagnoses of hypo-echoic renal tumor histotypes. Our study cohort comprised 103 clear cell renal cell carcinomas (ccRCCs), 24 papillary renal cell carcinomas (pRCCs), 28 chromophobe renal cell carcinomas (cRCCs), and 34 angiomyolipomas (AMLs), hypo-echoic on ultrasound, and imaged between January 2011 and December 2013. Enhancement homogeneity and tumor-to-cortex intensity ratio (TOC ratio) were retrospectively analyzed. Overall, heterogeneous enhancement was more common in ccRCCs than AMLs, pRCCs, and cRCCs. TOC ratio showed the trend ccRCC > AML > pRCC = cRCC. Similar trends were seen in tumors < 4 cm. Using heterogeneous enhancement or TOC ratio > 107.5% to differentiate ccRCC from other histotypes, the sensitivity, specificity, positive and negative predictive values were 93.1%, 74.5%, 84.8%, and 87.5%, respectively. Tumors > 4 cm exhibited considerable overlap in enhancement homogeneity among different histotypes. TOC ratios were similar between homo- and heterogeneously enhancing tumors for ccRCCs and for pRCCs and cRCCs, but higher in homogeneously enhancing than heterogeneously enhancing AMLs. In homo- and heterogeneously enhancing tumors, TOC ratios followed the trends ccRCCs > AMLs > pRCCs = cRCCs and ccRCCs > AMLs = pRCCs = cRCCs, respectively. With TOC ratio > 105.81% and > 72.37% to differentiate homo- and heterogeneously enhancing ccRCCs from other histotypes in tumors > 4 cm with same enhancement homogeneity, the sensitivity, specificity, positive and negative predictive values were 70.0%, 85.7%, 70.0%, 85.7%, and 91.7%, 94.4%, 95.7%, 89.5%, respectively. CEUS homogeneity and TOC ratio are helpful in differential diagnosis of hypo-echoic renal tumor histotypes. Diameter and enhancement homogeneity should be considered when deciding the diagnostic TOC ratio cutoff.
推荐引用方式
GB/T 7714：

Lu Qing,Xue Li-yun,Huang Bei-jian, et al. Histotype differentiation of hypo-echoic renal tumors on CEUS: usefulness of enhancement homogeneity and intensity [J].ABDOMINAL IMAGING,2015,40(6):1675-1683.
APA：

Lu Qing,Xue Li-yun,Huang Bei-jian,Wang Wen-ping,&Li Cui-xian.(2015).Histotype differentiation of hypo-echoic renal tumors on CEUS: usefulness of enhancement homogeneity and intensity .ABDOMINAL IMAGING,40(6):1675-1683.
MLA：

Lu Qing, et al. "Histotype differentiation of hypo-echoic renal tumors on CEUS: usefulness of enhancement homogeneity and intensity" .ABDOMINAL IMAGING 40,6(2015):1675-1683.

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