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Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China 期刊论文

编号：

630362a6-6295-4200-9a36-7357a4de34d5
作者：

Jin, Kaizhou(金凯舟)#^[1,2,3]Luo, Guopei(罗国培)^[1,2,3]Xu, Jin(徐近)^[1,2,3]Zhang, Bo(张波)^[1,2,3]Liu, Chen(刘辰)^[1,2,3]Ji, Shurong^[1,2,3];Liu, Liang(刘亮)^[1,2,3]Long, Jiang(龙江)^[1,2,3]Ni, Quanxing^[1,2,3];Yu, Xianjun(虞先濬)*^[1,2,3]
语种：

English
期刊：

ONCOLOGY LETTERS ISSN：1792-1074 2017 年 13 卷 5 期 (3163 - 3168) ; MAY
收录：
关键词：

pancreas neuroenclocrine neoplasm clinical outcome prognostic factor
摘要：

The aim of the present study was to investigate the clinical, pathological and prognostic characteristics of Chinese patients with resected pancreatic neuroendocrine neoplasms (p-NENs). Data from patients who were surgically treated and pathologically diagnosed with p-NENs at the Department of Pancreatic Oncology of the Fudan University Shanghai Cancer Center (Shanghai, China), between January 2003 and July 2015, were evaluated using univariate and multivariate analyses. A total of 162 patients with p-NENs met the criteria of the present study and were included in the analysis. Patients with poorly differentiated pancreatic neuroendocrine carcinoma (p-NEC) exhibited a significantly increased rate of lymph node metastasis, as compared with patients with grade (G)1/G2 pancreatic neuroendocrine tumors (p-NETs) (62.5 vs. 20.5%, P=0.003). univariate analysis identified that the following factors led to decreased overall survival (OS): Lymph node metastasis (P=0.001, vs. the absence of lymph node metastasis); distant metastasis (P=0.043, vs. the absence of distant metastasis); resection margin R1/R2 (P=0.030, vs. RO resection); NEC 03 (P<0.0011, vs. NET 01). Following the multivariate analysis, NEC 03 remained a statistically significant risk factor (HR=12.593; 95% CI, 3.476-45.622; P<0.001, vs. NET G1/G2). Furthermore, according to the proliferation marker protein K1-67 staining index, assigning a grade using the proliferative index (G1, <= 5% G2, >5-20%; G3, >20%) was more efficient for prognostic stratification compared with the European Neuroendocrine Tumor Society (Berlin, Germany)/ World Health Organization (Geneva, Switzerland) 2010 grading classification. The present study indicated that p-NEC was an important predictor of decreased OS in Chinese patients. Furthermore, a Ki-67 staining index of 5% represented a more efficient value for the distinction between G1 and G2.
推荐引用方式
GB/T 7714：

Jin Kaizhou,Luo Guopei,Xu Jin, et al. Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China [J].ONCOLOGY LETTERS,2017,13(5):3163-3168.
APA：

Jin Kaizhou,Luo Guopei,Xu Jin,Zhang Bo,&Yu Xianjun.(2017).Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China .ONCOLOGY LETTERS,13(5):3163-3168.
MLA：

Jin Kaizhou, et al. "Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China" .ONCOLOGY LETTERS 13,5(2017):3163-3168.

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