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Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations 期刊论文

编号：

64c95a1c-c3b4-4d57-8ef9-1032477faae7
作者：

Zhu, Xinyi(胡震)*^[1]Tian, Tian^[2];Ruan, Miao^[2];Rao, Jia^[2];Yang, Wentao(杨文涛)^[2]Cai, Xu(蔡旭)^[2]Sun, Menghong^[3];Qin, Guangqi^[3];Zhao, Zhonghua^[4];Wu, Jiong^[1];Shao, Zhimin(邵志敏)^[1]Shui, Ruohong(水若鸿)^[2]Hu, Zhen(胡震)*^[1]
语种：

English
期刊：

JOURNAL OF BREAST CANCER ISSN：1738-6756 2018 年 21 卷 3 期 (297 - 305) ; SEP
收录：
关键词：

BRCA1 genes BRCA2 genes Breast neoplasms DNA repair Poly (ADP-ribose) polymerase-1
摘要：

Purpose: The characteristic expression of DNA damage response proteins in familial breast cancers with BRCA1, BRCA2, or non-BRCA1/2 mutations has not been analyzed in Chinese patients. Our study aimed to assess the differential expression of microcephalin 1 (BRIT1), ATM serine/threonine kinase (ATM), checkpoint kinase 2 (CHEK2), BRCA1, RAD51 recombinase (RAD51), and poly (ADP-ribose) polymerase 1 (PARP-1) and establish the profile of Chinese familial breast cancers with different mutation status. Methods: We constructed five tissue microarrays from 183 familial breast cancer patients (31 with BRCA1 mutations; 14 with BRCA2 mutations, and 138 with non-BRCA1/2 mutations). The DNA response and repair markers used for immunohistochemistry analysis included BRIT1, ATM, CHEK2, BRCA1, RAD51, and PARP-1. The expressions of these proteins were analyzed in BRCA1/2 mutated tumors. The association between pathologic characteristics with BRCA1/2 mutation status was also analyzed. Results: In familial breast cancer patients, BRCA1 mutated tumors were more frequent with high nuclear grade, estrogen receptor/progesterone receptor/human epidermal growth factor receptor 2 negative, low Ki-67, and positive CK5/6. BRCA1 mutated tumors had lower CHEK2 and higher cytoplasmic BRIT1 expression than BRCA2 and non-BRCA1/2 mutation tumors. BRCA2-associated tumors showed higher CHEK2 and cytoplasmic RAD51 expression than those in other groups. Nuclear PARP-1 expression in BRCA1/2-associated tumors was significantly higher than in non-BRCA1/2 mutation tumors. Moreover, we found quite a few of negative PARP-1 expression cases in BRCA1/2 mutated groups. Conclusion: The clinicopathologic findings of BRCA1-associated Chinese familial breast cancers were similar to the results of other studies. Chinese familial breast cancer patients with BRCA1/2 mutations might have distinctive expression of different DNA damage response proteins. The reduced expression of PARP-1 in Chinese BRCA1/2 mutated breast cancer patients could influence the therapeutic outcome of PARP-1 inhibitors.
推荐引用方式
GB/T 7714：

Zhu Xinyi,Tian Tian,Ruan Miao, et al. Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations [J].JOURNAL OF BREAST CANCER,2018,21(3):297-305.
APA：

Zhu Xinyi,Tian Tian,Ruan Miao,Rao Jia,&Hu Zhen.(2018).Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations .JOURNAL OF BREAST CANCER,21(3):297-305.
MLA：

Zhu Xinyi, et al. "Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations" .JOURNAL OF BREAST CANCER 21,3(2018):297-305.

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