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Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation 期刊论文

编号：

65480744-5ffb-400e-95a5-192066a91f69
作者：

An, Jian^[1,2,3] Ren, Shancheng^[4] Murphy, Stephen J.^[5] Dalangood, Sumiya^[6] Chang, Cunjie^[6] Pang, Xiaodong^[7] Cui, Yangyan^[6] Wang, Liguo^[8] Pan, Yunqian^[1] Zhang, Xiaowei^[1] Zhu, Yasheng^[4] Wang, Chenji^[9] Halling, Geoffrey C.^[5] Cheng, Liang^[10] Sukov, William R.^[11] Karnes, R. Jeffrey^[2,5] Vasmatzis, George^[5,12] Zhang, Qing^[6] Zhang, Jun^[11] Cheville, John C.^[5,11] Yan, Jun^[6] Sun, Yinghao^[4] Huang, Haojie^[1,2,3]
语种：

English
期刊：

MOLECULAR CELL ISSN：1097-2765 2015 年 59 卷 6 期 (904 - 916) ; SEP 17
收录：
摘要：

SPOP mutations and TMPRSS2-ERG rearrangements occur collectively in up to 65% of human prostate cancers. Although the two events are mutually exclusive, it is unclear whether they are functionally interrelated. Here, we demonstrate that SPOP, functioning as an E3 ubiquitin ligase substrate-binding protein, promotes ubiquitination and proteasome degradation of wild-type ERG by recognizing a degron motif at the N terminus of ERG. Prostate cancer-associated SPOP mutations abrogate the SPOP-mediated degradation function on the ERG oncoprotein. Conversely, the majority of TMPRSS2-ERG fusions encode N-terminal-truncated ERG proteins that are resistant to the SPOP-mediated degradation because of degron impairment. Our findings reveal degradation resistance as a previously uncharacterized mechanism that contributes to elevation of truncated ERG proteins in prostate cancer. They also suggest that overcoming ERG resistance to SPOP-mediated degradation represents a viable strategy for treatment of prostate cancers expressing either mutated SPOP or truncated ERG.
推荐引用方式
GB/T 7714：

An Jian,Ren Shancheng,Murphy Stephen J., et al. Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation [J].MOLECULAR CELL,2015,59(6):904-916.
APA：

An Jian,Ren Shancheng,Murphy Stephen J.,Dalangood Sumiya,&Huang Haojie.(2015).Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation .MOLECULAR CELL,59(6):904-916.
MLA：

An Jian, et al. "Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation" .MOLECULAR CELL 59,6(2015):904-916.

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