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Targeting CREB Pathway Suppresses Small Cell Lung Cancer 期刊论文

编号：

65d39ecb-c984-462c-bb51-056e0ed1951d
作者：

Xia, Yifeng^[1,2];Zhan, Cheng(詹成)^[2]Feng, Mingxiang(冯明祥)^[2]Leblanc, Mathias^[3];Ke, Eugene^[1];Yeddula, Narayana^[1];Verma, Inder M.^[1];
语种：

English
期刊：

MOLECULAR CANCER RESEARCH ISSN：1541-7786 2018 年 16 卷 5 期 (825 - 832) ; MAY
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摘要：

Small cell lung cancer (SCLC) is the most deadly subtype of lung cancer due to its dismal prognosis. We have developed a lentiviral vector-mediated SCLC mouse model and have explored the role of both the NF-kB and CREB families of transcription factors in this model. Surprisingly, induction of NF-kB activity, which promotes tumor progression in many cancer types including non-small cell lung carcinoma (NSCLC), is dispensable in SCLC. Instead, suppression of NF-kB activity in SCLC tumors moderately accelerated tumor development. Examination of gene expression signatures of both mouse and human SCLC tumors revealed overall low NF-kB but high CREB activity. Blocking CREB activation by a dominant-negative form of PKA (dnPKA) completely abolished the development of SCLC. Similarly, expression of dnPKA or treatment with PKA inhibitor H89 greatly reduced the growth of SCLC tumors in syngeneic transplantation models. Altogether, our results strongly suggest that targeting CREB is a promising therapeutic strategy against SCLC. (C) 2018 AACR.
推荐引用方式
GB/T 7714：

Xia Yifeng,Zhan Cheng,Feng Mingxiang, et al. Targeting CREB Pathway Suppresses Small Cell Lung Cancer [J].MOLECULAR CANCER RESEARCH,2018,16(5):825-832.
APA：

Xia Yifeng,Zhan Cheng,Feng Mingxiang,Leblanc Mathias,&Verma Inder M..(2018).Targeting CREB Pathway Suppresses Small Cell Lung Cancer .MOLECULAR CANCER RESEARCH,16(5):825-832.
MLA：

Xia Yifeng, et al. "Targeting CREB Pathway Suppresses Small Cell Lung Cancer" .MOLECULAR CANCER RESEARCH 16,5(2018):825-832.

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