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Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines 期刊论文

编号：

66933a0d-2751-418e-b299-230a8572dab5
作者：

Wang, Yuheng^[1];Zhang, Bingbing^[1];Zheng, Yinying^[1];Ma, Qiaoning^[1];Sui, Qiang^[2];Lei, Xinsheng(雷新胜)*^[1]
语种：

英文
期刊：

TETRAHEDRON ISSN：0040-4020 2019 年 75 卷 8 期 (1064 - 1071) ; FEB 22
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关键词：

Imidazo[1,2-a]pyridine Zolpidem Minodronic acid Hydrodechlorination Coupling reaction
摘要：

Practical and scalable procedures for Minodronic acid and Zolpidem are developed with short reaction sequences from 2-aminopyridines and maleic anhydride, respectively. The new procedures avoid column chromatography for the purification in all synthetic steps. Key aspects of this development involve reductive hydrodechlorination and Suzuki coupling reaction of 2-chloroimidazole[1,2-a]pyridines, and their application towards synthesis of the two drugs is also addressed. (C) 2019 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Wang Yuheng,Zhang Bingbing,Zheng Yinying, et al. Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines [J].TETRAHEDRON,2019,75(8):1064-1071.
APA：

Wang Yuheng,Zhang Bingbing,Zheng Yinying,Ma Qiaoning,&Lei Xinsheng.(2019).Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines .TETRAHEDRON,75(8):1064-1071.
MLA：

Wang Yuheng, et al. "Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines" .TETRAHEDRON 75,8(2019):1064-1071.
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