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Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells 期刊论文

编号：

66cff659-fd7e-464d-bc21-ef77a4281824
作者：

Cui, Bai^[1,2];Luo, Yuanyuan^[1];Tian, Pengfei^[1];Peng, Fei^[1];Lu, Jinxin^[1,3];Yang, Yongliang^[4];Su, Qitong^[1];Liu, Bing^[1];Yu, Jiachuan^[1];Luo, Xi^[1];Yin, Liu^[5];Cheng, Wei^[1];An, Fan^[1];He, Bin^[2];Liang, Dapeng^[1];Wu, Sijin^[4];Chu, Peng^[1];Song, Luyao^[1];Liu, Xinyu^[3];Luo, Huandong^[1];Xu, Jie^[1];Pan, Yujia^[1];Wang, Yang^[1];Li, Dangsheng^[6];Huang, Peng^[2];Yang, Qingkai^[1];Zhang, Lingqiang^[7];Zhou, Binhua P.^[8];Liu, Suling(柳素玲)^[9,10]Xu, Guowang^[3];Lam, Eric WF^[11];Kelley, Keith W.^[12,13];Liu, Quentin^[1,2];
语种：

英文
期刊：

JOURNAL OF CLINICAL INVESTIGATION ISSN：0021-9738 2019 年 129 卷 3 期 (1030 - 1046) ; MAR 1
收录：
摘要：

Chronic stress triggers activation of the sympathetic nervous system and drives malignancy. Using an immunodeficient murine system, we showed that chronic stress-induced epinephrine promoted breast cancer stem-like properties via lactate dehydrogenase A-dependent (LDHA-dependent) metabolic rewiring. Chronic stress-induced epinephrine activated LDHA to generate lactate, and the adjusted pH directed USP28-mediated deubiquitination and stabilization of MYC. The SLUG promoter was then activated by MYC, which promoted development of breast cancer stem-like traits. Using a drug screen that targeted LDHA, we found that a chronic stress-induced cancer stem-like phenotype could be reversed by vitamin C. These findings demonstrated the critical importance of psychological factors in promoting stem-like properties in breast cancer cells. Thus, the LDHA-lowering agent vitamin C can be a potential approach for combating stress-associated breast cancer.
推荐引用方式
GB/T 7714：

Cui Bai,Luo Yuanyuan,Tian Pengfei, et al. Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells [J].JOURNAL OF CLINICAL INVESTIGATION,2019,129(3):1030-1046.
APA：

Cui Bai,Luo Yuanyuan,Tian Pengfei,Peng Fei,&Liu Quentin.(2019).Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells .JOURNAL OF CLINICAL INVESTIGATION,129(3):1030-1046.
MLA：

Cui Bai, et al. "Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells" .JOURNAL OF CLINICAL INVESTIGATION 129,3(2019):1030-1046.
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