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NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients 期刊论文

编号：

66e1eceb-b6d1-401d-9c87-5132f1df6046
作者：

Xu, Qinxia^[1];Qiu, Xiaoyan(邱晓燕)*^[1]Jiao, Zheng^[1];Zhang, Ming(张明)^[2]Chen, Jianping^[3];Zhong, Mingkang(钟明康)^[1]
语种：

English
期刊：

PHARMACOGENOMICS ISSN：1462-2416 2017 年 18 卷 4 期 (381 - 392) ; MAR
收录：
关键词：

cyclosporine NFATC1 NFATC2 pharmacodynamics PPIA PPP3CB PPP3R1 renal transplantation SNPs
摘要：

Aim: To investigate the effects of SNPs in the cyclophilin A/calcineurin/nuclear factor of activated T-cells (NFATs) pathway genes (PPIA, PPP3CB, PPP3R1, NFATC1 and NFATC2) on cyclosporine (CsA) efficacy in renal transplant recipients. Materials & methods: Seventy-six tag SNPs were detected in 155 CsA-treated renal recipients with at least a 5-year follow-up. The associations of SNPs with acute rejection, nephrotoxicity, pneumonia and estimated glomerular filtration rate post transplant were explored. Results: NFATC1 rs3894049 GC was a risk factor for acute rejection compared with CC carriers (p = 0.0005). NFATC1 rs2280055 TT carriers had a more stable estimated glomerular filtration rate level than CC (p = 0.0004). Conclusion: Detecting NFATC1 polymorphisms could help predict CsA efficacy in renal transplant patients.
推荐引用方式
GB/T 7714：

Xu Qinxia,Qiu Xiaoyan,Jiao Zheng, et al. NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients [J].PHARMACOGENOMICS,2017,18(4):381-392.
APA：

Xu Qinxia,Qiu Xiaoyan,Jiao Zheng,Zhang Ming,&Zhong Mingkang.(2017).NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients .PHARMACOGENOMICS,18(4):381-392.
MLA：

Xu Qinxia, et al. "NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients" .PHARMACOGENOMICS 18,4(2017):381-392.

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