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Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer 期刊论文

编号：

67918826-42ee-49ff-a25c-d9d66854a64d
作者：

Zou, Ran^[1,2];Cao, Wenbo^[1];Chong, Leelyn^[2,3];Hua, Wei(花玮)^[4]Xu, Hao^[4];Mao, Ying(毛颖)^[4]Page, Jessica^[5];Shi, Riyi^[5];Xia, Yu^[3,6];Hu, Tony Y.^[7];Zhang, Wenpeng^[3];Ouyang, Zheng^[1,2,3];
语种：

英文
期刊：

ANALYTICAL CHEMISTRY ISSN：0003-2700 2019 年 91 卷 1 期 (1157 - 1163) ; JAN 1
收录：
摘要：

The combination of direct sampling ionization and miniature mass spectrometer presents a promising technical pathway of point-of-care analysis in clinical applications. In this work, a miniature mass spectrometry system was used for analysis of tissue samples. Direct tissue sampling coupled with extraction spray ionization was used with a home-built miniature mass spectrometer, Mini 12. Lipid species in tissue samples were well profiled in rat brain, kidney, and liver in a couple of minutes. By incorporating a photochemical (Paterno-Bitchi) reaction, fast identification of lipid C=C location was realized. Relative quantitation of the lipid C=C isomer was performed by calculating the intensity ratio C=C diagnostic product ions, by which FA 18:1 (Delta 9)/FA 18:1 (Delta 11) was found to change significantly in mouse cancerous breast tissue samples. Accumulation of 2-hydroxylglutarate in human glioma samples, not in normal brains, can also be easily identified for rapid diagnosis.
推荐引用方式
GB/T 7714：

Zou Ran,Cao Wenbo,Chong Leelyn, et al. Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer [J].ANALYTICAL CHEMISTRY,2019,91(1):1157-1163.
APA：

Zou Ran,Cao Wenbo,Chong Leelyn,Hua Wei,&Ouyang Zheng.(2019).Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer .ANALYTICAL CHEMISTRY,91(1):1157-1163.
MLA：

Zou Ran, et al. "Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer" .ANALYTICAL CHEMISTRY 91,1(2019):1157-1163.
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