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Changes in intestinal microbiota in HIV-1-infected subjects following cART initiation: influence of CD4+T cell count 期刊论文

编号：

68d17108-dacd-4ca8-89e9-3325f4dced77
作者：

Ji, Yongjia^[1];Zhang, Fengdi^[1];Zhang, Renfang(张仁芳)^[1]Shen, Yinzhong(沈银忠)^[1]Liu, Li(刘莉)^[1]Wang, Jiangrong(王江蓉)^[1]Yang, Junyang(杨君洋)^[1]Tang, Qi(唐琪)^[1]Xun, Jingna^[1];Qi, Tangkai^[1];Wang, Zhenyan(王珍燕)^[1]Song, Wei(宋炜)^[1]Tang, Yang(汤阳)^[1]Chen, Jun^[1];Lu, Hongzhou(卢洪洲)*^[1,2,3]
语种：

英文
期刊：

EMERGING MICROBES & INFECTIONS ISSN：2222-1751 2018 年 7 卷 ; JUN 22
收录：
摘要：

The roles of immunodeficiency and combined antiretroviral therapy (cART) in shaping the gut microbiota in HIV-1-infected subjects (HISs) have not been described thoroughly by time-series investigations. In this study, 36 antiretroviral-naive HISs were enrolled to prospectively assess alterations in the fecal microbiota and plasma markers of microbial translocation and inflammation with cART. At baseline, the species alpha-diversity of the fecal microbiota was significantly lower in HISs with a CD4(+) T cell count <300/mm(3) than in HISs with a CD4(+) T cell count >300/mm(3) (Shannon index: Median 2.557 vs. 2.981, P= 0.006; Simpson index: Median 0.168 vs. 0.096, P= 0.004). Additionally, the baseline a-diversity indices correlated with CD4(+) T cell counts (Shannon index: r= 0.474, P= 0.004; Simpson index: r = -0.467, P = 0.004) and the specific plasma biomarkers for microbial translocation and inflammation. After cART introduction, the species a-diversity of fecal microbiota in HISs with CD4(+) T cell counts <300/mm(3) was significantly restored (Shannon index: Median 2.557 vs. 2.791, P = 0.007; Simpson index: Median 0.168 vs. 0.112, P = 0.004), while the variances were insignificant among HISs with CD4(+) T cell counts >300/mm(3) (Shannon index: Median 2.981 vs. 2.934, P = 0.179; Simpson index: Median 0.096 vs. 0.119, P = 0.082). Meanwhile, with cART introduction, alterations in the gut microbial composition were more significant in the subgroup with CD4(+) T cell counts >300/mm(3), corresponding to increases in the specific plasma inflammatory markers. These findings implicated the interactive roles of immunodeficiency and cART for affecting gut microbiota in HIV-1-infected individuals, providing new insights into intestinal microbiome dysbiosis related to HIV-1 infection.
推荐引用方式
GB/T 7714：

Ji Yongjia,Zhang Fengdi,Zhang Renfang, et al. Changes in intestinal microbiota in HIV-1-infected subjects following cART initiation: influence of CD4+T cell count [J].EMERGING MICROBES & INFECTIONS,2018,7.
APA：

Ji Yongjia,Zhang Fengdi,Zhang Renfang,Shen Yinzhong,&Lu Hongzhou.(2018).Changes in intestinal microbiota in HIV-1-infected subjects following cART initiation: influence of CD4+T cell count .EMERGING MICROBES & INFECTIONS,7.
MLA：

Ji Yongjia, et al. "Changes in intestinal microbiota in HIV-1-infected subjects following cART initiation: influence of CD4+T cell count" .EMERGING MICROBES & INFECTIONS 7(2018).
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