Background and aims. Cytokeratin19 positive (CK19(+)) hepatocellular carcinoma (HCC) is thought to derive from liver progenitor cells (LPC). However, whether peritumoralductular reaction (DR) differs between CK19(+) and CK19 negative (CK19(-) ) HCC patients remains unclear. Material and methods. hundred and twenty HBV-related HCC patients were enrolled in this study. Clinicopathological variables were collected, and immunohistochemistry staining for CK19, proliferating cell nuclear antigen (PCNA), interleukin-6 (IL-6) and beta-catenin were performed in tumor and peritumor liver tissues. Results.CK19(+) HCC patients had higher grade of peritumoral DR and proportion of proliferative DR than the CK19(-) group. The mean number or the proportion of cytoplasmic beta-catenin(+) DR was higher in the CK19(+) group than in the CK19(-) group. Furthermore, there were more patients with nuclear beta-catenin+ peritumoral DR in the CK19(+) group as compared to the CK19(-) group. Conclusion. Peritumoral DR was more abundant and proliferative in CK19(+) HCC patients, with higher level of nuclear translocation of beta-catenin. However, it is unclear whether peritumoral DR is the cause or result of poor prognosis in these patients
[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Gastroenterol, Shanghai, Peoples R China.
[2]Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai, Peoples R China.
[3]Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Lab Med, Shanghai, Peoples R China.
(8.0+极速模式)