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Genistein inhibits osteolytic bone metastasis and enhances bone mineral in nude mice 期刊论文

编号：

6a608077-e075-43ec-b9b0-7342dbde3baa
作者：

Zhang, Yanyan^[1];Zhu, Guoying(朱国英)*^[1]Gu, Shuzhu(顾淑珠)^[1]Chen, Xiao(陈晓)^[1]Hu, Heping^[1];Weng, Shifang^[1];
语种：

English
期刊：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY ISSN：1382-6689 2010 年 30 卷 1 期 (37 - 44) ; JUL
收录：
关键词：

Genistein Osteolytic bone metastasis Osteoclast Bone mass Bone microstructure
摘要：

In this study, the effective activity of genistein on osteolytic bone metastasis and bone mineral was investigated. Female BALB/c-nu/nu mice were injected with estrogen receptor-negative human breast cancer cells, MDA-MB-231, into left cardiac ventricle to form osteolytic bone metastases, and administered genistein subcutaneously after rachologically small but defined osteolytic metastases had been observed (protocol 1), simultaneously with cancer cells inoculation (protocol 2) and prophylactically 7 days before inoculation of cancer cells (protocol 3). In all protocols, genistein (10 mg/kg/day) markedly reduced the number and volume of osteolytic bone metastases assessed by radiography and the number of osteoclasts. Furthermore, histomorphometrical analysis revealed that genistein markedly increased trabecular area (Tb.Ar%), trabecular thickness (Tb.Th) and trabecular number (Tb.N), and decreased trabecular separation (Tb.Sp). These results thus demonstrate that genistein could inhibit osteolytic bone metastases, suppress bone resorption, increase bone mass and improve bone microstructure in bone metastases of breast cancer. (C) 2010 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Zhang Yanyan,Zhu Guoying,Gu Shuzhu, et al. Genistein inhibits osteolytic bone metastasis and enhances bone mineral in nude mice [J].ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2010,30(1):37-44.
APA：

Zhang Yanyan,Zhu Guoying,Gu Shuzhu,Chen Xiao,&Weng Shifang.(2010).Genistein inhibits osteolytic bone metastasis and enhances bone mineral in nude mice .ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,30(1):37-44.
MLA：

Zhang Yanyan, et al. "Genistein inhibits osteolytic bone metastasis and enhances bone mineral in nude mice" .ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 30,1(2010):37-44.

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