首页 / 院系成果 / 成果详情页

The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer 期刊论文

编号：

6b81972e-c54d-4e49-90b3-c07c05b7e432
作者：

Qiu, Junjun^[1,2,3];Wang, Yan^[4,5];Liu, Yinglei^[6];Zhang, Ying(张英)^[1,2,3]Ding, Jingxin(丁景新)^[1,2,3]Hua, Keqin^[1,2,3];
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2016 年 7 卷 22 期 (32478 - 32492) ; MAY 31
收录：
关键词：

ANRIL proliferation cell cycle apoptosis senescence
摘要：

Antisense non-coding RNA in the INK4 locus (ANRIL) has been implicated in a variety of cancers. In the present study, we evaluated ANRIL expression in epithelial ovarian cancer (EOC) and defined its clinical implications and biological functions. ANRIL was overexpressed in EOC tissues relative to normal controls. Overexpression correlated with advanced International Federation of Gynecologists and Obstetricians stage and high histological grade. Multivariate analysis indicated that ANRIL is an independent prognostic factor for overall survival in EOC. Gain-and loss-of-function experiments demonstrated that ANRIL promotes EOC cell proliferation both in vitro and in vivo. The proliferative effect was linked to the promotion of cell cycle progression and inhibition of apoptosis and senescence. Down-regulation of P15(INK4B) and up-regulation of Bcl-2 by ANRIL may partially explain ANRIL-induced EOC cell proliferation. This study is the first to establish that ANRIL promotes EOC progression and is a potential prognostic biomarker.
推荐引用方式
GB/T 7714：

Qiu Jun-jun,Wang Yan,Liu Ying-lei, et al. The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer [J].ONCOTARGET,2016,7(22):32478-32492.
APA：

Qiu Jun-jun,Wang Yan,Liu Ying-lei,Zhang Ying,&Hua Ke-qin.(2016).The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer .ONCOTARGET,7(22):32478-32492.
MLA：

Qiu Jun-jun, et al. "The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer" .ONCOTARGET 7,22(2016):32478-32492.

浏览次数：2  下载次数：0

分享到：

浏览次数：2

下载次数：0

打印次数：0