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Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer 期刊论文

编号：

6c2f6cd4-6e40-424e-affa-31a341b9d032
作者：

Li, Shibao^[1,2];Wu, Zhiyuan(吴之源)^[3]Chen, Yuming^[1];Kang, Zhihua(康志华)^[1]Wang, Hua^[1];He, Ping^[4];Zhang, Xinju^[5];Hu, Tingting^[1];Zhang, Qunfeng(张群峰)^[1,6]Cai, Yanqun^[1,7];Xu, Xiao^[5];Guan, Ming(关明)^[1,3,5]
语种：

English
期刊：

TUMOR BIOLOGY ISSN：1010-4283 2016 年 37 卷 4 期 (5365 - 5374) ; APR
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关键词：

Ephrin-A2 Gleason score Ki-67 Prostate cancer TNM staging
摘要：

Ephrin-A2, a member of the Eph/ephrin family, is associated with tumorigenesis and tumor progression. This study aimed to assess the diagnostic and prognostic value of both serum and tissue levels of Ephrin-A2 in prostate cancer (PCa) management. One hundred and forty-five frozen prostate tissues, 55 paraffin-embedded prostate tissues, 88 serum samples, and seven prostate cell lines (RWPE-1, LNCaP, LNCaP-LN3, PC-3, PC-3M, PC-3M-LN4, and DU145) were examined via quantitative reverse transcription-PCR (qRT-PCR), immunohistochemistry, enzyme-linked immunosorbent assay, and western blotting. Induced Ephrin-A2 messenger RNA (mRNA) or protein expression was detected in 8.6 % (5/58) benign prostatic hyperplasia (BPH), 59.8 % (52/87) PCa, and five prostate cancer cell lines. Ephrin-A2 immunostaining was present in 6.7 % (1/15) patients with BPHs and 62.5 % (25/40) clinically localized PCa. Accordingly, serum Ephrin-A2 was significantly higher in PCa patients compared to those in the BPH patients and controls (P < 0.001). The expression of Ephrin-A2 was higher in tumor patients with an elevated Gleason score or T3-T4 staging. Ephrin-A2 expression was correlated with Ki-67 expression in PCa patients, both at the gene scale and protein level. Our data indicate that Ephrin-A2 is a potential diagnostic and prognostic biomarker and a promising molecular therapeutic target to attenuate prostate cancer progression.
推荐引用方式
GB/T 7714：

Li Shibao,Wu Zhiyuan,Chen Yuming, et al. Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer [J].TUMOR BIOLOGY,2016,37(4):5365-5374.
APA：

Li Shibao,Wu Zhiyuan,Chen Yuming,Kang Zhihua,&Guan Ming.(2016).Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer .TUMOR BIOLOGY,37(4):5365-5374.
MLA：

Li Shibao, et al. "Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer" .TUMOR BIOLOGY 37,4(2016):5365-5374.

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