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IGFBP3 A-202C polymorphism and breast cancer susceptibility: a meta-analysis involving 33,557 cases and 45,254 controls 期刊论文

编号：

6d6742b2-03ce-4657-90e9-11ced06d68f6
作者：

Qiu, LiXin(邱立新)^[1,2]Yao, Lei^[3];Yuan, Hui^[4];Mao, Chen^[5];Chen, Bo^[6];Zhan, Ping^[7];Xue, Kai^[1,2];Zhang, Jian^[1,2];Hu, XiChun^[1,2];
语种：

English
期刊：

BREAST CANCER RESEARCH AND TREATMENT ISSN：0167-6806 2010 年 122 卷 3 期 (867 - 871) ; AUG
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关键词：

IGFBP3 Polymorphism Breast cancer Susceptibility Meta-analysis
摘要：

Published data on the association between insulin-like growth factor binding protein 3 (IGFBP3) A-202C polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between them. A total of 27 studies including 33,557 cases and 45,254 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with IGFBP3 C allele when all studies were pooled into the meta-analysis (CC vs. AA: OR = 1.06, 95% CI = 1.02-1.11; dominant model: OR = 1.04, 95% CI = 1.00-1.07). In the subgroup analysis by ethnicity, significantly increased risk was found for Caucasians (AC vs. AA: OR = 1.04, 95% CI = 1.00-1.08; CC vs. AA: OR = 1.05, 95% CI = 1.01-1.10; dominant model: OR = 1.04, 95% CI = 1.00-1.08) and Asians (CC vs. AA: OR = 1.35, 95% CI = 1.02-1.78; recessive model: OR = 1.38, 95% CI = 1.05-1.82). When stratified by study design, statistically significantly elevated risk was found among population-based studies (CC vs. AA: OR = 1.06, 95% CI = 1.01-1.11; dominant model: OR = 1.03, 95% CI = 1.00-1.07). In the subgroup analysis by menopausal status, no statistically significantly increased risk was found among premenopausal or postmenopausal women. In conclusion, this meta-analysis suggests that the IGFBP3 C allele is a low-penetrant risk factor for developing breast cancer.
推荐引用方式
GB/T 7714：

Qiu Li-Xin,Yao Lei,Yuan Hui, et al. IGFBP3 A-202C polymorphism and breast cancer susceptibility: a meta-analysis involving 33,557 cases and 45,254 controls [J].BREAST CANCER RESEARCH AND TREATMENT,2010,122(3):867-871.
APA：

Qiu Li-Xin,Yao Lei,Yuan Hui,Mao Chen,&Hu Xi-Chun.(2010).IGFBP3 A-202C polymorphism and breast cancer susceptibility: a meta-analysis involving 33,557 cases and 45,254 controls .BREAST CANCER RESEARCH AND TREATMENT,122(3):867-871.
MLA：

Qiu Li-Xin, et al. "IGFBP3 A-202C polymorphism and breast cancer susceptibility: a meta-analysis involving 33,557 cases and 45,254 controls" .BREAST CANCER RESEARCH AND TREATMENT 122,3(2010):867-871.

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