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Urinary paraben concentrations and their associations with anthropometric measures of children aged 3 years 期刊论文

编号：

6d802d8a-b4ce-4099-8389-c46845d172cb
作者：

Guo, Jianqiu(郭剑秋)#^[1]Wu, Chunhua(邬春华)*^[1]Lu, Dasheng^[1,2];Jiang, Shuai^[1,2];Liang, Weijiu^[3];Chang, Xiuli(常秀丽)^[1]Xu, Hao^[3];Wang, Guoquan^[2];Zhou, Zhijun(周志俊)^[1]
语种：

English
期刊：

ENVIRONMENTAL POLLUTION ISSN：0269-7491 2017 年 222 卷 (307 - 314) ; MAR
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关键词：

Parabens Exposure assessment Anthropometric measures Urine Child health
摘要：

Parabens, known as ubiquitous preservatives, have been linked to adverse health outcomes in humans. This study aimed to examine urinary paraben concentrations of children at 3 years of age and evaluate their associations with anthropometric parameters. Urinary parabens including methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP) and benzylparaben (BeP) were measured among 436 children in a birth cohort using gas chromatography with tandem mass spectrometry. Generalized linear models were performed to evaluate associations of paraben exposures with age-and sex-specific z scores, including weight, height, weight for height and body mass index. MeP, EtP and PrP were the dominant parabens in urinary samples, with the median concentrations of 6.03 mu g/L, 3.17 mu g/L, 2.40 mu/L, respectively. The median values of estimated daily intake (EDl(urine)) of five urinary paraben concentrations were 12.10, 5.68, 4.50, 0.06 and 0.17 mu g/kg-body weight/day, respectively. Urinary EtP concentrations were positively associated with weight z scores [regression coefficient beta = 0.16, 95% confidence interval (CI): 0.04, 0.29; p = 0.01] and height z scores ([beta = 0.15, 95% CI: 0.03, 0.27; p = 0.01). Positive associations were found between the sum of molar concentrations of five parabens and height z scores among all children ((beta = 0.24, 95% CI: 0.04, 0.45; p = 0.02). These significant associations were only observed in boys. Our findings suggest that exposure to parabens may be adversely associated with physical growth in 3-year-old boy children. Further prospective studies are warranted to understand the toxicological mechanisms of paraben exposures and potential risk of children. (C) 2016 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Guo Jianqiu,Wu Chunhua,Lu Dasheng, et al. Urinary paraben concentrations and their associations with anthropometric measures of children aged 3 years [J].ENVIRONMENTAL POLLUTION,2017,222:307-314.
APA：

Guo Jianqiu,Wu Chunhua,Lu Dasheng,Jiang Shuai,&Zhou Zhijun.(2017).Urinary paraben concentrations and their associations with anthropometric measures of children aged 3 years .ENVIRONMENTAL POLLUTION,222:307-314.
MLA：

Guo Jianqiu, et al. "Urinary paraben concentrations and their associations with anthropometric measures of children aged 3 years" .ENVIRONMENTAL POLLUTION 222(2017):307-314.

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