Osteoarthritis prevalence is expected to increase markedly in the Asia-Pacific region due to rapid population aging. Identifying effective and safe therapeutic options to manage osteoarthritic pain is viewed as a priority. The Asia-Pacific Experts on Topical Analgesics Advisory Board developed consensus statements for use of topical NSAIDs in musculoskeletal pain. Evidence supporting these statements in osteoarthritic pain was reviewed. Best available evidence indicates that topical NSAIDs have a moderate effect on relief of osteoarthritic pain, comparable to that of oral NSAIDs but with a better risk-to-benefit ratio. International clinical practice guidelines recommend topical NSAIDs on par with or ahead of oral NSAIDs for pain management in patients with knee and hand osteoarthritis, and as the first-line choice in persons aged >= 75 years.
[1]Med City, Dept Phys Med & Rehabil, Ortigas Po 1605, Philippines.
[2]Cardinal Santos Med Ctr, Orthopaed Sports & Regenerat Med, San Juan 1500, Metro Manila, Philippines.
[3]Sime Darby Med Ctr, Subang Jaya 47500, Malaysia.
[4]Phayao Hosp, Dept Orthoped, Phayao 56000, Thailand.
[5]Phramongkutklao Army Hosp, Dept Orthoped, Bangkok 10400, Thailand.
[6]Fudan Univ, Ctr Sports Med, Huashan Hosp, Dept Orthoped Sports Med, Shanghai 200000, Peoples R China.
[7]Union Hosp, Minimally Invas Ctr, Shatin, Hong Kong, Peoples R China.
[8]Bach Mai Hosp, Rehabil Ctr, Hanoi, Vietnam.
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