Background: In recent years novel human respiratory disease agents have been described for Southeast Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with a strong phylogenetic relationship to orthoreoviruses of bat origin. Results: In this report, we isolated a novel Melaka-like reovirus (named "Cangyuan virus") from intestinal content samples of one fruit bat residing in China's Yunnan province. Phylogenetic analysis of the whole Cangyuan virus genome sequences of segments L, M and S demonstrated the genetic diversity of the Cangyuan virus. In contrast to the L and M segments, the phylogenetic trees for the S segments of Cangyuan virus demonstrated a greater degree of heterogeneity. Conclusions: Phylogenetic analysis indicated that the Cangyuan virus was a novel orthoreovirus and substantially different from currently known members of Pteropine orthoreovirus (PRV) species group.
[1]Chengdu Mil Reg, Ctr Dis Control & Prevent, Chengdu, Peoples R China.
[2]Acad Mil Med Sci, Inst Mil Vet, Changchun 130062, Peoples R China.
[3]Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Shanghai 200030, Peoples R China.
[4]Anim Epidem Dis Control Ctr, Kunming 650032, Yunnan Province, Peoples R China.
[5]Chengdu Mil Reg PLA, Gen Hosp, Chengdu 610083, Peoples R China.
(8.0+极速模式)