Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. However, there has not been an explicit description of applying EGs as a vehicle for hypertrophic scars treatment. Here, a novel transdermal EGs loaded with 5-fluorouracil (5-FU EGs) was successfully prepared and characterized. The stability assay in vitro revealed that 5-FU EGs stored for a period of 30 days at 4 +/- 1 degrees C had a better size stability than that at 25 +/- 1 degrees C. Furthermore, using confocal laser scanning microscopy, EGs labeled with Rhodamine 6 G penetrated into the deep dermis of the hypertrophic scar within 24 h in the rabbit ear hypertrophic model suggested that the EGs were an optional delivery carrier through scar tissues. In addition, the value of the Scar Elevation Index (SEI) of 5-FU EGs group in the rabbit ear scar model was lower than that of 5-FU Phosphate Buffered Saline gel and Control groups. To conclude, these results suggest that EGs delivery system loaded 5-fluorouracil is a perfect candidate drug for hypertrophic scars therapy in future.
[1]Shanghai Jiao Tong Univ, Sch Med, Dept Human Anat Histol & Embryol, Shanghai 200025, Peoples R China.
[2]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Shanghai 200011, Peoples R China.
[3]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Dermatol, Shanghai 200011, Peoples R China.
[4]Shanghai Jiao Tong Univ, Inst Micronano Sci & Technol, Natl Key Lab Nano Micro Fabricat Technol, Key Lab Thin Film & Microfabricat,Minist Educ, Shanghai 200240, Peoples R China.
[5]Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 3, Dept Otolaryngol Head & Neck Surg, Shanghai 201900, Peoples R China.
[6]Fudan Univ, Huashan Hosp, Dept Orthopaed Sports Med, Shanghai 200040, Peoples R China.
(8.0+极速模式)