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Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis 期刊论文

编号：

717f45bf-51d5-4b4a-884c-14a72a68380f
作者：

Huang, JiaLin^[1];Jiang, Gan^[1];Song, QingXiang^[1];Gu, Xiao^[1];Hu, Meng^[1];Wang, XiaoLin^[1];Song, HuaHua^[1];Chen, LePei^[1];Lin, YingYing^[2];Jiang, Di^[3,4];Chen, Jun(陈钧)^[3,4]Feng, JunFeng^[2];Qiu, YongMing^[2];Jiang, JiYao^[2];Jiang, XinGuo(蒋新国)^[3,4]Chen, HongZhuan^[1];Gao, XiaoLing^[1];
语种：

English
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2017 年 8 卷 ; MAY 10
收录：
摘要：

Hyperactivated Ras regulates many oncogenic pathways in several malignant human cancers including glioblastoma and it is an attractive target for cancer therapies. Ras activation in cancer cells drives protein internalization via macropinocytosis as a key nutrient-gaining process. By utilizing this unique endocytosis pathway, here we create a biologically inspired nanostructure that can induce cancer cells to 'drink drugs' for targeting activating transcription factor-5 (ATF5), an overexpressed anti-apoptotic transcription factor in glioblastoma. Apolipoprotein E3-reconstituted high-density lipoprotein is used to encapsulate the siRNA-loaded calcium phosphate core and facilitate it to penetrate the blood-brain barrier, thus targeting the glioblastoma cells in a macropinocytosis-dependent manner. The nanostructure carrying ATF5 siRNA exerts remarkable RNA-interfering efficiency, increases glioblastoma cell apoptosis and inhibits tumour cell growth both in vitro and in xenograft tumour models. This strategy of targeting the macropinocytosis caused by Ras activation provides a nanoparticle-based approach for precision therapy in glioblastoma and other Ras-activated cancers.
推荐引用方式
GB/T 7714：

Huang Jia-Lin,Jiang Gan,Song Qing-Xiang, et al. Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis [J].NATURE COMMUNICATIONS,2017,8.
APA：

Huang Jia-Lin,Jiang Gan,Song Qing-Xiang,Gu Xiao,&Gao Xiao-Ling.(2017).Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis .NATURE COMMUNICATIONS,8.
MLA：

Huang Jia-Lin, et al. "Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis" .NATURE COMMUNICATIONS 8(2017).

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