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Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma 期刊论文

编号：

719d1c09-a789-4e7b-8358-8781424a3d24
作者：

Liu, Chenglin^[1] Zhang, YuHang^[2] Deng, Qinfang^[3] Li, Yixue^[1,4,5] Huang, Tao^[2] Zhou, Songwen^[3] Cai, YuDong^[6]
语种：

English
期刊：

BIOMED RESEARCH INTERNATIONAL ISSN：2314-6133 2017 年
收录：
摘要：

The regulation of transcriptome expression level is a complex process involving multiple-level interactions among molecules such as protein coding RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA), which are essential for the transcriptome stability and maintenance and regulation of body homeostasis. The availability of multilevel expression data enables a comprehensive view of the regulatory network. In this study, we analyzed the coding and noncoding gene expression profiles of 301 patients with uterine corpus endometrial carcinoma (UCEC). A new method was proposed to construct a genome-wide integrative network based on variance inflation factor (VIF) regression method. The cross-regulation relations of mRNA, lncRNA, and miRNA were then selected based on clique-searching algorithm from the network, when any two molecules of the three were shown as interacting according to the integrative network. Such relation, which we call them RNA-lncRNA-miRNA triplet, demonstrated the complexity in transcriptome regulation process. Finally, six UCEC-related triplets were selected in which the mRNA participates in endometrial carcinoma pathway, such as CDH1 and TP53. The multi-type RNAs are proved to be cross-regulated as to each of the six triplets according to literature. All the triplets demonstrated the association with the initiation and progression of UCEC. Our method provides a comprehensive strategy for the investigation of transcriptome regulation mechanism.
推荐引用方式
GB/T 7714：

Liu Chenglin,Zhang Yu-Hang,Deng Qinfang, et al. Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma [J].BIOMED RESEARCH INTERNATIONAL,2017.
APA：

Liu Chenglin,Zhang Yu-Hang,Deng Qinfang,Li Yixue,&Cai Yu-Dong.(2017).Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma .BIOMED RESEARCH INTERNATIONAL.
MLA：

Liu Chenglin, et al. "Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma" .BIOMED RESEARCH INTERNATIONAL(2017).

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