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Is there a role of surgery in patients with recurrent or metastatic gastrointestinal stromal tumours responding to imatinib: A prospective randomised trial in China 期刊论文

编号：

728725d1-18b1-4944-863c-9450904602d6
作者：

Du, ChunYan^[1,2] Zhou, Ye^[1,2] Song, Chun^[3] Wang, YongPeng^[3] Jie, ZhiGang^[4] He, YuLong^[5] Liang, XiaoBo^[6] Cao, Hui^[7] Yan, ZhongShu^[8] Shi, YingQiang^[1,2]
语种：

English
期刊：

EUROPEAN JOURNAL OF CANCER ISSN：0959-8049 2014 年 50 卷 10 期 (1772 - 1778) ; JUL
收录：
关键词：

Gastrointestinal stromal tumours Imatinib mesylate Surgery
摘要：

Objectives: For advanced gastrointestinal stromal tumour (GIST) patients who are responding to imatinib mesylate, the role of surgery has not been formally demonstrated. This multicenter randomised controlled trial was designed to assess whether surgery to treat residual disease for patients with recurrent/metastatic GISTs responding to imatinib mesylate (IM) improved progression free survival (PFS) compared with IM treatment alone. Methods: Between 3 and 12 months after starting IM for recurrent/metastatic GISTs, eligible patients were randomised to two arms: Arm A (surgery for residual disease) and Arm B (IM treatment alone). In Arm A (19 pts), surgery was performed to remove residual macroscopic lesions as completely as possible, and IM treatment continued after surgery. In Aim B (22 pts), IM was given alone at a dose of 400 mg per day until disease progression. The primary end-point was PFS measured from the date IM started. This study was registered in the ChiCTR registry with the ID number ChiCTR-TRC-00000244. Results: This randomised trial was closed early due to poor accrual. Only 41 patients were enrolled as opposed to 210 patients planned. 2-year PFS was 88.4% in the surgery arm and 57.7% in the IM-alone arm (P = 0.089). Median overall survival (mOS) was not reached in the surgery arm and 49 months in patients with IM-alone arm (P = 0.024). Conclusions: While no significant differences were observed in the two arms, this study suggests that surgical removal of the metastatic lesion may improve the outcome of advanced GIST patients and should stimulate additional research on this topic. (C) 2014 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Du Chun-Yan,Zhou Ye,Song Chun, et al. Is there a role of surgery in patients with recurrent or metastatic gastrointestinal stromal tumours responding to imatinib: A prospective randomised trial in China [J].EUROPEAN JOURNAL OF CANCER,2014,50(10):1772-1778.
APA：

Du Chun-Yan,Zhou Ye,Song Chun,Wang Yong-Peng,&Shi Ying-Qiang.(2014).Is there a role of surgery in patients with recurrent or metastatic gastrointestinal stromal tumours responding to imatinib: A prospective randomised trial in China .EUROPEAN JOURNAL OF CANCER,50(10):1772-1778.
MLA：

Du Chun-Yan, et al. "Is there a role of surgery in patients with recurrent or metastatic gastrointestinal stromal tumours responding to imatinib: A prospective randomised trial in China" .EUROPEAN JOURNAL OF CANCER 50,10(2014):1772-1778.

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