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Long-Term Clinical Outcome of Intensity-Modulated Radiotherapy for Inoperable Non-Small Cell Lung Cancer: The MD Anderson Experience 期刊论文

编号：

7380c275-d5ec-41d3-b1bc-e63e6407a043
作者：

Jiang, ZhiQin^[5] Yang, Kunyu^[6] Komaki, Ritsuko Wei, Xiong Tucker, Susan L.^[3] Zhuang, Yan^[2] Martel, Mary K.^[2] Vedam, Sastray^[2] Balter, Peter^[2] Zhu, Guangying^[7] Gomez, Daniel Lu, Charles^[4] Mohan, Radhe^[2] Cox, James D. Liao, Zhongxing^[1]
语种：

English
期刊：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS ISSN：0360-3016 2012 年 83 卷 1 期 (332 - 339) ; MAY 1
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关键词：

Non-small-cell lung cancer IMRT Early and late toxicity Radiation-induced toxicity
摘要：

Purpose: In 2007, we published our initial experience in treating inoperable non-small-cell lung cancer (NSCLC) with intensity-modulated radiation therapy (IMRT). The current report is an update of that experience with long-term follow-up. Methods and Materials: Patients in this retrospective review were 165 patients who began definitive radiotherapy, with or without chemotherapy, for newly diagnosed, pathologically confirmed NSCLC to a dose of >= 60 Gy from 2005 to 2006. Early and late toxicities assessed included treatment-related pneumonitis (TRP), pulmonary fibrosis, esophagitis, and esophageal stricture, scored mainly according to the Common Terminology Criteria for Adverse Events 3.0. Other variables monitored were radiation-associated dermatitis and changes in body weight and Karnofsky performance status. The Kaplan-Meier method was used to compute survival and freedom from radiation-related acute and late toxicities as a function of time. Results: Most patients (89%) had Stage III to IV disease. The median radiation dose was 66 Gy given in 33 fractions (range, 60-76 Gy, 1.8-2.3 Gy per fraction). Median overall survival time was 1.8 years; the 2-year and 3-year overall survival rates were 46% and 30%. Rates of Grade >= 3 maximum TRP (TRPmax) were 11% at 6 months and 14% at 12 months. At 18 months, 86% of patients had developed Grade >= 1 maximum pulmonary fibrosis (pulmonary fibrosis(max)) and 7% Grade >= 2 pulmonary fibrosis(max). The median times to maximum esophagitis (esophagitis(max)) were 3 weeks (range, 1-13 weeks) for Grade 2 and 6 weeks (range, 3-13 weeks) for Grade 3. A higher percentage of patients who experienced Grade 3 esophagitismax later developed Grade 2 to 3 esophageal stricture. Conclusions: In our experience, using IMRT to treat NSCLC leads to low rates of pulmonary and esophageal toxicity, and favorable clinical outcomes in terms of survival. (C) 2012 Elsevier Inc.
推荐引用方式
GB/T 7714：

Jiang Zhi-Qin,Yang Kunyu,Komaki Ritsuko, et al. Long-Term Clinical Outcome of Intensity-Modulated Radiotherapy for Inoperable Non-Small Cell Lung Cancer: The MD Anderson Experience [J].INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2012,83(1):332-339.
APA：

Jiang Zhi-Qin,Yang Kunyu,Komaki Ritsuko,Wei Xiong,&Liao Zhongxing.(2012).Long-Term Clinical Outcome of Intensity-Modulated Radiotherapy for Inoperable Non-Small Cell Lung Cancer: The MD Anderson Experience .INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,83(1):332-339.
MLA：

Jiang Zhi-Qin, et al. "Long-Term Clinical Outcome of Intensity-Modulated Radiotherapy for Inoperable Non-Small Cell Lung Cancer: The MD Anderson Experience" .INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 83,1(2012):332-339.

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