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Complete regression of xenograft tumors using biodegradable mPEG-PLA-SN38 block copolymer micelles 期刊论文

编号：

74eaa7de-4b76-4f9e-acd0-381bf17cf09e
作者：

Lu Lu(陆录)^[1,2,3]Zheng Yan^[1,2,3];Weng Shuqiang(翁书强)^[4]Zhu Wenwei(朱文伟)^[1,2,3]Chen Jinhong(陈进宏)^[1,2,3]Zhang Xiaomin^[5];Lee, Robert J.^[6];Bo Yu^[5];Jia Huliang(贾户亮)^[1,2,3]Qin Lunxiu(钦伦秀)^[1,2,3]
语种：

English
期刊：

COLLOIDS AND SURFACES B-BIOINTERFACES ISSN：0927-7765 2016 年 142 卷 (417 - 423) ; JUN 1
收录：
关键词：

Block co-polymers SN38 Micelles Cancer Regression
摘要：

7-Ethyl-10-hydroxy-comptothecin (SN38) is an active metabolite of irinotecan (CPT-11) and the clinical application of SN38 is limited by its hydrophobicity and instability. To address these issues, a series of novel amphiphilic mPEG-PLA-SN38-conjugates were synthesized by linking SN38 to mPEG-PLA-SA, and they could form micelles by self-assembly. The effects of mPEG-PLA composition were studied in vitro and in vivo. The mean diameters of mPEG(2K)-PLA-SN38 micelles and mPEG(4K)-PLA-SN38 micelles were 10-20 nm and 120 nm, respectively, and mPEG(2K)-PLA-SN38 micelles showed greater antitumor efficacy than mPEG(4K)-PLA-SN38 micelles both in vitro and in vivo. These data suggest that the lengths of mPEG and PLA chains had a major impact on the physicochemical characteristics and antitumor activity of SN38-conjugate micelles. (C) 2016 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Lu Lu,Zheng Yan,Weng Shuqiang, et al. Complete regression of xenograft tumors using biodegradable mPEG-PLA-SN38 block copolymer micelles [J].COLLOIDS AND SURFACES B-BIOINTERFACES,2016,142:417-423.
APA：

Lu Lu,Zheng Yan,Weng Shuqiang,Zhu Wenwei,&Qin Lunxiu.(2016).Complete regression of xenograft tumors using biodegradable mPEG-PLA-SN38 block copolymer micelles .COLLOIDS AND SURFACES B-BIOINTERFACES,142:417-423.
MLA：

Lu Lu, et al. "Complete regression of xenograft tumors using biodegradable mPEG-PLA-SN38 block copolymer micelles" .COLLOIDS AND SURFACES B-BIOINTERFACES 142(2016):417-423.

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