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The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice 期刊论文

编号：

74efe3a4-ec81-49a9-a933-4ddf078d6da5
作者：

Du, Yarui^[1];Liu, Bo^[1];Guo, Fan^[1];Xu, Guifang^[1];Ding, Yuqiang^[2];Liu, Yong^[3];Sun, Xin^[4];Xu, Guoliang(徐国良)*^[1]
语种：

英文
期刊：

PLOS ONE ISSN：1932-6203 2012 年 7 卷 10 期 ; OCT 15
收录：
摘要：

Methyl-CpG binding domain protein 5 (MBD5) belongs to the MBD family proteins, which play central roles in transcriptional regulation and development. The significance of MBD5 function is highlighted by recent studies implicating it as a candidate gene involved in human 2q23.1 microdeletion syndrome. To investigate the physiological role of Mbd5, we generated knockout mice. The Mbd5-deficient mice showed growth retardation, wasting and pre-weaning lethality. The observed growth retardation was associated with the impairment of GH/IGF-1 axis in Mbd5-null pups. Conditional knockout of Mbd5 in the brain resulted in the similar phenotypes as whole body deletion, indicating that Mbd5 functions in the nervous system to regulate postnatal growth. Moreover, the mutant mice also displayed enhanced glucose tolerance and elevated insulin sensitivity as a result of increased insulin signaling, ultimately resulting in disturbed glucose homeostasis and hypoglycemia. These results indicate Mbd5 as an essential factor for mouse postnatal growth and maintenance of glucose homeostasis.
推荐引用方式
GB/T 7714：

Du Yarui,Liu Bo,Guo Fan, et al. The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice [J].PLOS ONE,2012,7(10).
APA：

Du Yarui,Liu Bo,Guo Fan,Xu Guifang,&Xu Guoliang.(2012).The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice .PLOS ONE,7(10).
MLA：

Du Yarui, et al. "The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice" .PLOS ONE 7,10(2012).

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