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PD-1/PD-L pathway inhibits M.tb-specific CD4(+) T-cell functions and phagocytosis of macrophages in active tuberculosis 期刊论文

编号：

7543e254-b5b5-4fcb-9e3c-7a955dffad2f
作者：

Shen, Lei^[1,2];Gao, Yan(高岩)^[2]Liu, Yuanyuan(刘袁媛)^[2]Zhang, Bingyan(张冰琰)^[2]Liu, Qianqian(刘倩倩)^[2]Wu, Jing(吴晶)^[2]Fan, Lin^[3];Ou, Qinfang^[4];Zhang, Wenhong(张文宏)^[2,5,6]Shao, Lingyun(邵凌云)*^[2]
语种：

English
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2016 年 6 卷 ; DEC 7
收录：
摘要：

The role of the PD-1/PD-L pathway in a murine model of tuberculosis remains controversial regarding viral infections and clinical tuberculosis. We conducted a case-control study to investigate the modulating role and mechanism of the PD-1/PD-L pathway in patients with active tuberculosis. Fiftynine participants, including 43 active tuberculosis (ATB) patients and 16 healthy controls (HC), were enrolled. Cell surface staining and flow cytometry were used to detect the expressions of PD-1 and its ligands on T cells and monocytes. Intracellular cytokine staining was used to determine the PPD-specific IFN-gamma-secreting T-cell proportion. CD4(+) T-cell proliferation and macrophage functions were investigated in the presence or absence of PD-1/PD-L pathway blockade. Proportions of both PD-1(+) CD4(+) and PDL1(+) CD4(+) T cells in ATB patients were more significantly increased than in the HC group (P = 0.0112 and P = 0.0141, respectively). The expressions of PD-1, PD-L1, and PD-L2 on CD14(+) monocytes in ATB patients were much higher than those in the HC group (P = 0.0016, P = 0.0001, and P = 0.0088, respectively). Blockade of PD-1 could significantly enhance CD4(+) T-cell proliferation (P = 0.0433). Phagocytosis and intracellular killing activity of macrophages increased significantly with PD-1/PD-L pathway blockade. In conclusion, the PD-1/PD-L pathway inhibits not only M.tb-specific CD4(+) T-cellmediated immunity but also innate immunity.
推荐引用方式
GB/T 7714：

Shen Lei,Gao Yan,Liu Yuanyuan, et al. PD-1/PD-L pathway inhibits M.tb-specific CD4(+) T-cell functions and phagocytosis of macrophages in active tuberculosis [J].SCIENTIFIC REPORTS,2016,6.
APA：

Shen Lei,Gao Yan,Liu Yuanyuan,Zhang Bingyan,&Shao Lingyun.(2016).PD-1/PD-L pathway inhibits M.tb-specific CD4(+) T-cell functions and phagocytosis of macrophages in active tuberculosis .SCIENTIFIC REPORTS,6.
MLA：

Shen Lei, et al. "PD-1/PD-L pathway inhibits M.tb-specific CD4(+) T-cell functions and phagocytosis of macrophages in active tuberculosis" .SCIENTIFIC REPORTS 6(2016).

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