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Effect of tumor size on prognosis of node-negative lung cancer with sufficient lymph node examination and no disease extension 期刊论文

编号：

7607e89d-c58d-4e55-8250-b9c09eafe8c3
作者：

Zhang, Yang^[1,2];Sun, Yihua(孙艺华)*^[1,2]Chen, Haiquan(陈海泉)*^[1,2,3,4]
语种：

English
期刊：

ONCOTARGETS AND THERAPY ISSN：1178-6930 2016 年 9 卷 (649 - 653)
收录：
关键词：

non-small-cell lung cancer tumor size prognosis
摘要：

Background: The effect of tumor size on the prognosis of node-negative non-small-cell lung cancer (NSCLC) might be biased by missed lymph node metastasis and local disease extension. Methods: We investigated 2,260 patients with N0M0 NSCLC in the Surveillance, Epidemiology and End Results (SEER) database diagnosed from 1998 to 2012. Eligible patients had >= 18 lymph nodes examined and no disease extension. Tumor size was classified as T1a (0-10 mm), T1b (11-20 mm), T1c (21-30 mm), T2a (31-40 mm), T2b (41-50 mm), T3 (51-70 mm), and T4 (>70 mm). Results: The 5-year cancer-specific survival (CSS) rates for T1a, T1b, T1c, T2a, T2b, T3, and T4 patients were 85.6%, 84.4%, 79.9%, 77.9%, 70.0%, 63.0%, and 61.7%, respectively. The 5-year overall survival (OS) rates for T1a, T1b, T1c, T2a, T2b, T3, and T4 patients were 77.8%, 74.1%, 68.2%, 64.5%, 58.7%, 53.2%, and 57.3%, respectively. Using T1a as the reference, the hazard ratio generally increased with tumor size in the multivariate analysis of CSS and OS, with the exception of T4 patients. Conclusion: After adjusting for lymph node examination and disease extension, tumor size still had a significant effect on CSS in NSCLC, although the effect seemed to be smaller than that in a more generalized population.
推荐引用方式
GB/T 7714：

Zhang Yang,Sun Yihua,Chen Haiquan, et al. Effect of tumor size on prognosis of node-negative lung cancer with sufficient lymph node examination and no disease extension [J].ONCOTARGETS AND THERAPY,2016,9:649-653.
APA：

Zhang Yang,Sun Yihua,Chen Haiquan.(2016).Effect of tumor size on prognosis of node-negative lung cancer with sufficient lymph node examination and no disease extension .ONCOTARGETS AND THERAPY,9:649-653.
MLA：

Zhang Yang, et al. "Effect of tumor size on prognosis of node-negative lung cancer with sufficient lymph node examination and no disease extension" .ONCOTARGETS AND THERAPY 9(2016):649-653.

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