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Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all-cause mortality in hemodialysis patients: A prospective cohort study 期刊论文

编号：

7633d36d-89f1-4b54-aafc-af62cdfaf285
作者：

Xiang, Fangfang(项方方)#^[1,2]Chen, Rongyi^[1,3];Cao, Xuesen(曹学森)^[1]Shen, Bo(沈波)^[1]Liu, Zhonghua(刘中华)^[1]Tan, Xiao(谭笑)^[1]Ding, Xiaoqiang(丁小强)*^[1,2]Zou, Jianzhou(邹建洲)*^[1,3]
语种：

English
期刊：

HEMODIALYSIS INTERNATIONAL ISSN：1492-7535 2018 年 22 卷 1 期 (82 - 92) ; JAN
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关键词：

Hemodialysis cardiovascular disease mortality inflammation monocyte/lymphocyte ratio
摘要：

Introduction: Patients with chronic kidney disease, especially those with end-stage renal disease, have an increased risk of death. Previous studies have suggested neutrophil/lymphocyte ratio (NLR) was related to worse outcome in patients undergoing hemodialysis (HD). However, monocyte/lymphocyte ratio (MLR) has not been evaluated in HD patients. In this study, we prospectively studied the predictive value of MLR for all-cause and cardiovascular mortality in HD patients and compared it with NLR.& para;& para;Methods: Patients who had been on a HD treatment for at least 6 months were enrolled. MLR was calculated by dividing the monocyte count by the lymphocyte count. Survival outcomes were estimated using the Kaplan-Meier method and compared by the log-rank test. Univariate and multivariate analyses were performed to evaluate the prognostic impact of MLR and other clinical factors on all-cause and cardiovascular mortality.& para;& para;Results: Mortality rates for the lowest, middle, and highest MLR textile group were 3.65, 7.02, and 11.15, respectively per 100 patient-years. The Kaplan-Meier analysis revealed that survival rates were significantly different among three MLR groups (P < 0.001). In multivariate Cox regression analyses, MLR was independently associated with all-cause mortality (HR 4.842; 95% CI, 2.091-11.214; P< 0.001) and cardiovascular mortality (HR 6.985, 95% CI 1.943-25.115, P = 0.003) as continuous variables. NLR was not an independent predictor of all-cause nor cardiovascular mortality after adjusted with MLR.& para;& para;Conclusions: The main finding of the study suggest that higher MLR was a strong and independent predictor of all-cause and cardiovascular mortality and overwhelmed NLR among HD patients.
推荐引用方式
GB/T 7714：

Xiang Fangfang,Chen Rongyi,Cao Xuesen, et al. Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all-cause mortality in hemodialysis patients: A prospective cohort study [J].HEMODIALYSIS INTERNATIONAL,2018,22(1):82-92.
APA：

Xiang Fangfang,Chen Rongyi,Cao Xuesen,Shen Bo,&Zou Jianzhou.(2018).Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all-cause mortality in hemodialysis patients: A prospective cohort study .HEMODIALYSIS INTERNATIONAL,22(1):82-92.
MLA：

Xiang Fangfang, et al. "Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all-cause mortality in hemodialysis patients: A prospective cohort study" .HEMODIALYSIS INTERNATIONAL 22,1(2018):82-92.

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