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Oxaliplatin antagonizes HIV-1 latency by activating NF-kappa B without causing global T cell activation 期刊论文

编号：

782f0391-31a7-4aec-8fed-dd9c09edf85d
作者：

Zhu, Xiaoli^[1] Liu, Sijie^[1] Wang, Pengfei^[1] Qu, Xiying^[1] Wang, Xiaohui^[1] Zeng, Hanxian^[1] Chen, Huabiao^[2,3] Zhu, Huanzhang^[1]
语种：

English
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2014 年 450 卷 1 期 (202 - 207) ; JUL 18
收录：
关键词：

Oxaliplatin HIV-1 latency Synergistic reactivation NF-kappa B transcription factor
摘要：

Reactivation of latent HIV-1 is a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current agents, identification of new latency activators is urgently required. Using an established model of HIV-1 latency, we examined the effect of Oxaliplatin on latent HIV-1 reactivation. We showed that Oxaliplatin, alone or in combination with valproic acid (VPA), was able to reactivate HIV-1 without inducing global T cell activation. We also provided evidence that Oxaliplatin reactivated HIV-1 expression by inducing nuclear factor kappa B (NF-kappa B) nuclear translocation. Our results indicated that Oxaliplatin could be a potential drug candidate for anti-latency therapies. (C) 2014 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Zhu Xiaoli,Liu Sijie,Wang Pengfei, et al. Oxaliplatin antagonizes HIV-1 latency by activating NF-kappa B without causing global T cell activation [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,450(1):202-207.
APA：

Zhu Xiaoli,Liu Sijie,Wang Pengfei,Qu Xiying,&Zhu Huanzhang.(2014).Oxaliplatin antagonizes HIV-1 latency by activating NF-kappa B without causing global T cell activation .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,450(1):202-207.
MLA：

Zhu Xiaoli, et al. "Oxaliplatin antagonizes HIV-1 latency by activating NF-kappa B without causing global T cell activation" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 450,1(2014):202-207.

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