[1]Shanghai Jiao Tong University School of Medicine, Department of Radiology,Shanghai,China
[2]Huadong Hospital, Department of Neurology,Shanghai,China
[3]Fudan University, Department of Nuclear Medicine,Shanghai,China
[4]Fudan University, Department of Neurology,Shanghai,China
[5]Huadong Hospital, Department of Oncology,Shanghai,China
[6]Taizhou Hospital, Department of Cardiovascular Diseases,Linhai,China
[7]
[8]Hefei University of Technology, Department of Building Environment and Equipment,Hefei,China
Objective To investigate the characteristics of cerebral blood perfusion in the patients with mild cognitive impairment (MCI) by comparing to normal controls and to evaluate the potential roles of SPECT in identifying subjects with MCI from normal aging. Methods Twenty patients, who were diagnosed as having MCI, and 20 normal aging subjects each underwent a 99 mTc-ethylcysteinate dime SPECT cerebral blood perfusion imaging. SPECT images were processed with SPM5b software and performed a voxel-based statistical analysis comparing MCI patients and normal aging subjects. Results In comparison with normal controls, subjects with MCI showed asymmetry hypoperfusion in the posterior cingulate gyrus, inferior and superior parietal lobule, cingulate gyrus, inferior and superior frontal gyrus. Conclusion Hypoperfusion is detected in reletively specific region in the patients with MCI and the clinical use of cerebral blood perfusion imaging for the detection of MCI is promising.
(8.0+极速模式)