首页 / 院系成果 / 成果详情页

Immunotherapy using IL-2 and GM-CSF is a potential treatment for multidrug-resistant Mycobacterium tuberculosis 期刊论文

编号：

78875671-b0b5-443f-9b13-386d8a5f6515
作者：

Zhang YongRong^[2];Liu Jian^[2];Wang Yong^[3,4];Xian QiaoYang^[3,4];Shao LingYun(邵凌云)^[5]Yang Zhong^[1];Wang XiaoNing^[1,2];
语种：

English
期刊：

SCIENCE CHINA-LIFE SCIENCES ISSN：1674-7305 2012 年 55 卷 9 期 (800 - 806) ; SEP
收录：
关键词：

tuberculosis MDR-TB IL-2 GM-CSF immunotherapy
摘要：

This study investigated the therapeutic effects of interleukin (IL)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF) co-administrated with antibacterial agents isoniazid (INH) and rifampin (RIF) to treat a mouse model of tuberculosis (TB) infection. A drug-susceptible TB strain, H37Rv was used to infect mice and the effectiveness of IL-2 and GM-CSF was initially evaluated based on survival rate, bacterial counts in lungs and spleens and the pathological condition of the lungs. Next, the therapeutic effect of the immunotherapy regimen was assessed in multidrug-resistant strain OB35-infected mice. In the H37Rv infection model, IL-2 and GM-CSF monotherapies reduced bacterial numbers in the lungs by 0.82 (P < 0.01) and 0.58 (P < 0.05) lg colony-forming units (CFU), respectively, and in the spleens by 1.42 (P < 0.01) and 1.22 (P < 0.01) lg CFU, respectively, compared with the untreated group. Mice receiving immunotherapy developed fewer lesions in the lungs compared with mice receiving antibacterial therapy alone. In the OB35 infection model, immunotherapy with either cytokine resulted in a significant reduction of bacterial load in the lungs and spleens and less severe lesions in the lungs compared with the untreated or antibacterial therapy treated mice. Notably, mice receiving immunotherapy with both cytokines had a 30% survival rate which was higher than that in other treated groups, and had significantly less CFUs in the lungs and spleens (1.02 and 1.34 lg CFU) compared with antibacterial therapy alone (P < 0.01). This study demonstrated that immunotherapy with both IL-2 and GM-CSF may be useful to treat multidrug resistant tuberculosis (MDR-TB).
推荐引用方式
GB/T 7714：

Zhang YongRong,Liu Jian,Wang Yong, et al. Immunotherapy using IL-2 and GM-CSF is a potential treatment for multidrug-resistant Mycobacterium tuberculosis [J].SCIENCE CHINA-LIFE SCIENCES,2012,55(9):800-806.
APA：

Zhang YongRong,Liu Jian,Wang Yong,Xian QiaoYang,&Wang XiaoNing.(2012).Immunotherapy using IL-2 and GM-CSF is a potential treatment for multidrug-resistant Mycobacterium tuberculosis .SCIENCE CHINA-LIFE SCIENCES,55(9):800-806.
MLA：

Zhang YongRong, et al. "Immunotherapy using IL-2 and GM-CSF is a potential treatment for multidrug-resistant Mycobacterium tuberculosis" .SCIENCE CHINA-LIFE SCIENCES 55,9(2012):800-806.

浏览次数：13  下载次数：0

分享到：

浏览次数：13

下载次数：0

打印次数：0