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Regioselective hydroxylation of lathyrane diterpenoids biocatalyzed by microorganisms and its application in integrated synthesis 期刊论文

编号：

792d41a6-0e79-4314-996c-834acad0df8c
作者：

Wu, Yiqing ^[1];Yin, Chengle(尹成乐)^[1]Cao, Yue ^[1];Liu, Xin ^[1];Yu, Jinxiang ^[1];Zhang, Jian ^[2];Yu, Boyang ^[2];Cheng, Zhihong(程志红)^[1]
语种：

英文
期刊：

Journal of Molecular Catalysis B: Enzymatic ISSN：1381-1177 2017 年 ; 19-Aug-16
收录：
摘要：

The regioselective oxidation of three lathyrane diterpenoids (lathyrol, 1; 7尾-hydroxylathyrol, 2; and Euphorbia factor L3, 3) catalyzed by the fungi Mortierella ramanniana CGMCC 3.03413, Mucor circinelloides CICC 40242, and the actinomycete Nocardia iowensis sp. nov. NRRL 5646 was investigated. Ten new metabolites (4-13) including two unprecedented cyclopropane-rearranged products (4 and 5) have been obtained. Metabolites (6, 10 and 11) were further converted chemically to eight acylated derivatives (6a, 10a-10f and 11a). The structures of all compounds were elucidated on the basis of extensive NMR and MS data analyses. All the metabolites and enzyme-chemical products were evaluated for their cytotoxicities against three human cancer cell lines as well as their multidrug resistance (MDR) reversing effects in adriamycin (ADM)-resistant human MCF-7 breast cancer cells (MCF-7/ADM). 漏 2017 Elsevier B.V.
推荐引用方式
GB/T 7714：

Wu Yiqing (1),Yin Chengle (1),Cao Yue (1), et al. Regioselective hydroxylation of lathyrane diterpenoids biocatalyzed by microorganisms and its application in integrated synthesis [J].Journal of Molecular Catalysis B: Enzymatic,2017.
APA：

Wu Yiqing (1),Yin Chengle (1),Cao Yue (1),Liu Xin (1),&Cheng Zhihong (1).(2017).Regioselective hydroxylation of lathyrane diterpenoids biocatalyzed by microorganisms and its application in integrated synthesis .Journal of Molecular Catalysis B: Enzymatic.
MLA：

Wu Yiqing (1), et al. "Regioselective hydroxylation of lathyrane diterpenoids biocatalyzed by microorganisms and its application in integrated synthesis" .Journal of Molecular Catalysis B: Enzymatic(2017).

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