首页 / 院系成果 / 成果详情页

High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection 期刊论文

编号：

7a9fd87e-6073-4abf-af01-ce42a4db3d86
作者：

Zhu, Liuluan^[1,4] Liu, Lu Zhang, Yue^[1,4] Pu, Lin^[2] Liu, Jingyuan^[2] Li, Xingwang^[3] Chen, Zhihai^[3] Hao, Yu^[1,4] Wang, Beibei^[1,4] Han, Junyan^[1,4] Li, Guoli^[1,4] Liang, Shuntao^[1,4] Xiong, Haofeng^[2] Zheng, Hong^[7] Li, Ang^[2] Xu, Jianqing^[5,6] Zeng, Hui^[1,4]
语种：

英文
期刊：

JOURNAL OF INFECTIOUS DISEASES ISSN：0022-1899 2018 年 217 卷 3 期 (428 - 437) ; FEB 1
收录：
关键词：

H1N1 H7N9 interleukin-8 MODS neutrophil extracellular traps
摘要：

Background. Most patients with severe infection with influenza A virus (IAV) progress to acute respiratory distress syndrome and even multiple organ dysfunction syndrome (MODS). Neutrophil extracellular traps (NETs) can be induced by pathogens and are responsible for immune tissue damage. We conducted a prospective study on the production and effects of NETs in H7N9 and H1N1 patients.
Methods. We investigated NET production in plasma and supernatant of cultured neutrophils by measuring cell-free deoxyribonucleic acid (DNA) and myeloperoxidase (MPO)-DNA complexes with PicoGreen dye and enzyme-linked immunosorbent assay methods, respectively. We also observed NET structure by immunofluorescence staining.
Results. We found that patients with severe influenza showed elevated plasma NET level on the day of admission. Neutrophils from these patients showed higher capacity to release MPO-DNA complex in response to interleukin-8 or lipopolysaccharide stimulation. We also found that NETs from H7N9 and H1N1 patients increased the permeability of alveolar epithelial cells, and, consequently, NET production was positively correlated with acute physiology and chronic health evaluation (APACHE) II score and MODS.
Conclusions. These data indicate that high level of NETs contributes to lung injury and is correlated with severity of disease. Thus, NETs might be a key factor to predict the poor prognosis in IAV patients.
推荐引用方式
GB/T 7714：

Zhu Liuluan,Liu Lu,Zhang Yue, et al. High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection [J].JOURNAL OF INFECTIOUS DISEASES,2018,217(3):428-437.
APA：

Zhu Liuluan,Liu Lu,Zhang Yue,Pu Lin,&Zeng Hui.(2018).High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection .JOURNAL OF INFECTIOUS DISEASES,217(3):428-437.
MLA：

Zhu Liuluan, et al. "High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection" .JOURNAL OF INFECTIOUS DISEASES 217,3(2018):428-437.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：21  下载次数：0

分享到：

浏览次数：21

下载次数：0

打印次数：0