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The beta-fibrinogen gene 455G/A polymorphism associated with cardioembolic stroke in atrial fibrillation with low CHA(2)DS(2)-VaSc score 期刊论文

编号：

7b505550-1130-401b-86e4-8080d1a3feb8
作者：

Hu, Xiaofeng^[1] Wang, Junjun^[2] Li, Yaguo^[2] Wu, Jiong^[2] Qiao, Song^[2] Xu, Shanhu^[2] Huang, Jun^[3] Chen, Linhui^[2]
语种：

English
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2017 年 7 卷 ; DEC 13
收录：
摘要：

Previous work has suggested that ischemic stroke (IS) may be more likely to occur in individuals with a genetic predisposition. In this study, we investigated the potential association of IS-relevant genetic risk factors with cardioembolic stroke (CES) in atrial fibrillation (AF) patients with low CHA2DS2-VaSc score. Genotyping was performed using the GenomeLab SNPstream genotyping platform for five IS-relevant SNPs (MMP-9 C1562T, ALOX5AP SG13S114A/T, MTHFR 677 C/T, FGB 455 G/A, and eNOS G298A) in 479 AF patients with CES and 580 age and sex-matched AF patients without CES. The multivariate analysis adjusted for potential confounders and demonstrated that FGB 455 G/A was independently associated with increased risk of CES in AF patients and the significance remained after Bonferroni correction in the additive, dominant, and recessive models with ORs of 1.548 (95% CI: 1.251-1.915, P = 0.001), 1.588 (95% CI: (1.226-2.057, P = 0.003), and 2.394 (95% CI: 1.357-4.223, P = 0.015), respectively. Plasma fibrinogen levels were significantly higher in patients with the A allele compared with patients with genotype of GG (3.29 +/- 0.38 mg/dl vs. 2.87 +/- 0.18 mg/dl, P < 0.001). We found for the first time that the A allele of FGB 455 G/A was a risk factor for CES in AF patients, probably by elevating the level of plasma fibrinogen.
推荐引用方式
GB/T 7714：

Hu Xiaofeng,Wang Junjun,Li Yaguo, et al. The beta-fibrinogen gene 455G/A polymorphism associated with cardioembolic stroke in atrial fibrillation with low CHA(2)DS(2)-VaSc score [J].SCIENTIFIC REPORTS,2017,7.
APA：

Hu Xiaofeng,Wang Junjun,Li Yaguo,Wu Jiong,&Chen Linhui.(2017).The beta-fibrinogen gene 455G/A polymorphism associated with cardioembolic stroke in atrial fibrillation with low CHA(2)DS(2)-VaSc score .SCIENTIFIC REPORTS,7.
MLA：

Hu Xiaofeng, et al. "The beta-fibrinogen gene 455G/A polymorphism associated with cardioembolic stroke in atrial fibrillation with low CHA(2)DS(2)-VaSc score" .SCIENTIFIC REPORTS 7(2017).

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