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Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus  期刊论文   WOS高被引论文

  • 编号：
    7bf06f24-0573-4026-b03c-9ee768375f65
  • 作者：
    Scirica, Benjamin M.[2,3] Bhatt, Deepak L.[1,2,3,4] Braunwald, Eugene[2,3] Steg, P. Gabriel[5,6] Davidson, Jaime[7] Hirshberg, Boaz[9] Ohman, Peter[9] Frederich, Robert[10] Wiviott, Stephen D.[2,3] Hoffman, Elaine B.[2,3] Cavender, Matthew A.[2,3] Udell, Jacob A.[2,3] Desai, Nihar R.[2,3] Mosenzon, Ofri[11] McGuire, Darren K.[8] Ray, Kausik K.[12] Leiter, Lawrence A.[13] Raz, Itamar[11,251] Braunwald, Eugene[2,3] Bhatt, Deepak L.[1,2,3,4] Scirica, Benjamin M.[2,3] Udell, Jacob A.[2,3] Cavender, Matthew A.[2,3] Desai, Nihar Abrahamsen, Timothy Grossman, Michelle Morin, Suzanne Im, Kyungah Hoffman, Elaine Gabovitch, Daniel Pricken, Alexandra Mosenzon, Ofri[11] Buskila, Alona Ohman, Peter[9] Hirshberg, Boaz[9] Stahre, Christina Price, Deborah BillingClason, Solveig Sabel, Karin Monyak, John Sjostrand, Mikalea Wei, Cheryl Lu, Jane Miller, Elinor Raichlen, Joel Fitt, Sandy Frederich, Robert[10] Iqbal, Nayyar Donovan, Mark Davidson, Jaime A. Steg, Ph. Gabriel AguilarSalinas, Carlos[314] Alvarsson, Michael[467] Amerena, John[36] Ardissino, Diego[274] Averkov, Oleg Avogaro, Angelo[287] Barnett, Anthony Bretzel, Reinhard Chiang, ChernEn Codoceo, Verner Corbalan, Ramon Dalby, Anthony Darius, Harald Deerochanawong, Chaicharn[486] Dellborg, Mikael[471] Eliaschewitz, Freddy[49] GarciaCastillo, Armando Gomis, Ramon Henry, Patrick[168] Hoekstra, Joost Jermendy, Gyorgy[205] Kastelein, John Keech, Anthony Kiss, Robert[222] Krempf, Michel[170] Laakso, Markku Leiter, Lawrence Leitersdorf, Eran Lewis, Basil[265] Litwak, Leon LopezSendon, Jose Ma, Ronald[190] McGuire, Darren Medina, Felix[345] Moses, Robert Nicolau, Jose C. Opolski, Grzegorz Ophuis, Ton Oude Paolasso, Ernesto Ray, Kausik K.[12] Ruda, Mikhail Kumar, K. M. Prasanna[233] Shestakova, Marina[407] Sheu, Wayne HH Smahelova, Alena[148] Bhupathiraju, B. Soma Raju Spinar, Jindrich[143] Sritata, Piyamitr[484] Strojeck, Krysztof VillenaChavez, Jaime E. Jia, Weiping Huo, Young Wiviott, Stephen D.[2,3] Lowe, Cheryl Awtry, Eric Berger, Clifford Desai, Akshay S. Gelfand, Eli Leeman, David Link, Mark Ruberg, Frederick Vita, Joseph Rost, Natalia Silverman, Scott Greenberger, Norton J. Lerch, Markus M. Gersh, Bernard Nesto, Richard Del Prato, Stefano Tuomilehto, Jaakko Kelsey, Sheryl Alvarisqueta, A.[14] Cuadrado, J.[15] Rista, L.[16] Hermida, S.[17] Baccaro, C.[18] Luquez, C.[19] Lagrutta, M.[20] Maffei, L.[21] Bartolacci, I.[22] Montana, O.[23] Cutuli, H.[24] Berli, M.[25] Lorenzatti, A.[26] Frechtel, G.[27] La Greca, R.[28] Fretes, O.[29] Diaz, M.[30] Rodriguez Papini, N.[31] Farias, E.[32] Issa, C.[33] Elbert, A.[34] Lehman, R.[35] Arya, M.[37] Singh, B.[38] Colquhoun, D.[39] Jayasinghe, R.[40] de Looze, F.[41,43] Blombery, P.[42] Ward, G.[44] Szto, G.[45] Abhayaratna, W.[46] Borges, J.[47] Russo, L.[48] Felicio, J.[50] Santos, F.[51] Guimaraes Filho, F.[52] Lazaretti Castro, M.[53] Rossi, P.[54] Armaganijan, D.[55] Leaes, P.[56] Bandeira, F.[57] Franken, M.[58] Rassi, N.[59] Rea, R.[60] Zanella, M.[61] Amodeo, C.[55] Cesar, L.[58] Betti, R.[58] Chacra, A.[62] Schmid, H.[63] Bell, A.[64] Syan, G.[65] Zadra, R.[66] Conter, H.[67] Dumas, R.[68] Borts, D.[69] Dattani, I.[70] Poirier, P.[71] Cha, J. 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  • 语种：
    英文
  • 期刊：
    NEW ENGLAND JOURNAL OF MEDICINE ISSN：0028-4793 2013 年 369 卷 14 期 (1317 - 1326) ; OCT 3
  • 收录：
     
  • 摘要：

    BackgroundThe cardiovascular safety and efficacy of many current antihyperglycemic agents, including saxagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, are unclear.
    MethodsWe randomly assigned 16,492 patients with type 2 diabetes who had a history of, or were at risk for, cardiovascular events to receive saxagliptin or placebo and followed them for a median of 2.1 years. Physicians were permitted to adjust other medications, including antihyperglycemic agents. The primary end point was a composite of cardiovascular death, myocardial infarction, or ischemic stroke.
    ResultsA primary end-point event occurred in 613 patients in the saxagliptin group and in 609 patients in the placebo group (7.3% and 7.2%, respectively, according to 2-year Kaplan-Meier estimates; hazard ratio with saxagliptin, 1.00; 95% confidence interval [CI], 0.89 to 1.12; P=0.99 for superiority; P<0.001 for noninferiority); the results were similar in the on-treatment analysis (hazard ratio, 1.03; 95% CI, 0.91 to 1.17). The major secondary end point of a composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, coronary revascularization, or heart failure occurred in 1059 patients in the saxagliptin group and in 1034 patients in the placebo group (12.8% and 12.4%, respectively, according to 2-year Kaplan-Meier estimates; hazard ratio, 1.02; 95% CI, 0.94 to 1.11; P=0.66). More patients in the saxagliptin group than in the placebo group were hospitalized for heart failure (3.5% vs. 2.8%; hazard ratio, 1.27; 95% CI, 1.07 to 1.51; P=0.007). Rates of adjudicated cases of acute and chronic pancreatitis were similar in the two groups (acute pancreatitis, 0.3% in the saxagliptin group and 0.2% in the placebo group; chronic pancreatitis, <0.1% and 0.1% in the two groups, respectively).
    ConclusionsDPP-4 inhibition with saxagliptin did not increase or decrease the rate of ischemic events, though the rate of hospitalization for heart failure was increased. Although saxagliptin improves glycemic control, other approaches are necessary to reduce cardiovascular risk in patients with diabetes.

  • 推荐引用方式
    GB/T 7714：
    Scirica Benjamin M.,Bhatt Deepak L.,Braunwald Eugene, et al. Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus [J].NEW ENGLAND JOURNAL OF MEDICINE,2013,369(14):1317-1326.
  • APA：
    Scirica Benjamin M.,Bhatt Deepak L.,Braunwald Eugene,Steg P. Gabriel,&Simmons D..(2013).Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus .NEW ENGLAND JOURNAL OF MEDICINE,369(14):1317-1326.
  • MLA：
    Scirica Benjamin M., et al. "Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus" .NEW ENGLAND JOURNAL OF MEDICINE 369,14(2013):1317-1326.
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