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Cytotoxic isoprenylated xanthones from Cudrania tricuspidata  期刊论文  

  • 编号:
    7c8fed24-7b66-4223-bebe-a962a819bf07
  • 作者:
    Zou, YS;Hou, AJ(侯爱君); Zhu, GF;Chen, YF;Sun, HD;Zhao, QS;
  • 语种:
    English
  • 期刊:
    BIOORGANIC & MEDICINAL CHEMISTRY ISSN:0968-0896 2004 年 12 卷 8 期 (1947 - 1953) ; APR 15
  • 收录:
  • 摘要:

    Eight new isoprenylated xanthones, cudratricusxanthones A-H (1-8), were isolated from the roots of Cudrania tricuspidata, together with ten known compounds, cudraxanthones H (9) and M (10), xanthone V,a (11), toxyloxanthone C (12), macluraxanthone B (13), 1-hydroxy-3, 6, 7-trimethoxyxanthone (14), cycloartocarpesin (15), artocarpesin (16), cudraflavone B (17), and kaempferol (18). Their structures were characterized by spectroscopic methods. Xanthones 5, 7, 10, and 12 showed inhibitory effects on four kinds of human digestive apparatus tumor cell lines (HCT-116, SMMC-7721, SGC-7901, and BGC-823) with IC50 values of 1.6-11.8 mug/mL. Xanthones 2, 4, and 11 displayed significant cytotoxicity against HCT-116, SMMC-7721, and SGC-7901 (IC50 = 1.3-9.8 mug/mL). Flavonoids 15-17 were almost inactive. (C) 2004 Elsevier Ltd. All rights reserved.

  • 推荐引用方式
    GB/T 7714:
    Zou YS,Hou AJ,Zhu GF, et al. Cytotoxic isoprenylated xanthones from Cudrania tricuspidata [J].BIOORGANIC & MEDICINAL CHEMISTRY,2004,12(8):1947-1953.
  • APA:
    Zou YS,Hou AJ,Zhu GF,Chen YF,&Zhao QS.(2004).Cytotoxic isoprenylated xanthones from Cudrania tricuspidata .BIOORGANIC & MEDICINAL CHEMISTRY,12(8):1947-1953.
  • MLA:
    Zou YS, et al. "Cytotoxic isoprenylated xanthones from Cudrania tricuspidata" .BIOORGANIC & MEDICINAL CHEMISTRY 12,8(2004):1947-1953.
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